Leronlimab
Leronlimab Basic information
- Product Name:
- Leronlimab
- Synonyms:
-
- Leronlimab
- Research Grade Leronlimab(DHE85401)
- Research Grade Leronlimab
- Leronlimab (anti-CCR5)
- CAS:
- 674782-26-4
- MW:
- 0
- Mol File:
- Mol File
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Leronlimab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Leronlimab Usage And Synthesis
Uses
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer[1].
in vivo
Leronlimab (2 mg; i.p., twice a week) reduces lung metastasis in murine xenograft models[1].
| Animal Model: | Female NCI Athymic nu/nu nude mice with MB-MDA-231 cells expressing Luc2-eGFP injection[1] |
| Dosage: | 2 mg |
| Administration: | Intraperitoneal injection; 2 mg, twice a week |
| Result: | Reduced the volume of pulmonary metastases at 8 weeks. |
References
[1] Jiao X, et al. Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. Breast Cancer Res. 2021 Jan 23;23(1):11. DOI:10.1186/s13058-021-01391-1
LeronlimabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com
Beijing Solarbio Science & Tecnology Co., Ltd.
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- 010-50973130 18101056239
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TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Guangzhou Hongyuan Chemical Co.,Ltd
- Tel
- 15817493340
- 981810490@qq.com