Leronlimab

Product Name: Leronlimab
CAS No.: 674782-26-4
Chemical Name: Leronlimab
Synonyms: Leronlimab;Leronlimab (anti-CCR5);Research Grade Leronlimab;Research Grade Leronlimab(DHE85401)
CBNumber: CB68081083
Formula Weight: 0
MOL File: Mol file

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Leronlimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Leronlimab Chemical Properties,Usage,Production

Uses

Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer[1].

in vivo

Leronlimab (2 mg; i.p., twice a week) reduces lung metastasis in murine xenograft models^[1].

Animal Model:	Female NCI Athymic nu/nu nude mice with MB-MDA-231 cells expressing Luc2-eGFP injection^[1]
Dosage:	2 mg
Administration:	Intraperitoneal injection; 2 mg, twice a week
Result:	Reduced the volume of pulmonary metastases at 8 weeks.

References

[1] Jiao X, et al. Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. Breast Cancer Res. 2021 Jan 23;23(1):11. DOI:10.1186/s13058-021-01391-1

Leronlimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Leronlimab Suppliers

China 21 United States 1 Global 22

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
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Guangzhou Hongyuan Chemical Co.,Ltd

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Wuhan Chemstan Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
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Biolab Reagents

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Wuhan Jingkangen Biomedical Technology Co., Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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Email: customer_service@efebio.com
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674782-26-4, LeronlimabRelated Search:

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Leronlimab

Research Grade Leronlimab(DHE85401)

Research Grade Leronlimab

Leronlimab (anti-CCR5)

674782-26-4