ChemicalBook > CAS DataBase List > Leronlimab
Leronlimab
- Product Name
- Leronlimab
- CAS No.
- 674782-26-4
- Chemical Name
- Leronlimab
- Synonyms
- Leronlimab;Leronlimab (anti-CCR5);Research Grade Leronlimab;Research Grade Leronlimab(DHE85401)
- CBNumber
- CB68081083
- Formula Weight
- 0
- MOL File
- Mol file
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Leronlimab Property
- form
- Liquid
- color
- Colorless to light yellow
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Leronlimab Chemical Properties,Usage,Production
Uses
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer[1].
in vivo
Leronlimab (2 mg; i.p., twice a week) reduces lung metastasis in murine xenograft models[1].
| Animal Model: | Female NCI Athymic nu/nu nude mice with MB-MDA-231 cells expressing Luc2-eGFP injection[1] |
| Dosage: | 2 mg |
| Administration: | Intraperitoneal injection; 2 mg, twice a week |
| Result: | Reduced the volume of pulmonary metastases at 8 weeks. |
References
[1] Jiao X, et al. Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. Breast Cancer Res. 2021 Jan 23;23(1):11. DOI:10.1186/s13058-021-01391-1
Leronlimab Preparation Products And Raw materials
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Preparation Products
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