4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-benzamide Chemical Properties

Melting point:

>188°C (dec.)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Solid

color 

Pale Red to Red

Stability:

Hygroscopic

InChI

InChI=1S/C14H12BNO4/c16-14(17)9-1-3-11(4-2-9)20-12-5-6-13-10(7-12)8-19-15(13)18/h1-7,18H,8H2,(H2,16,17)

InChIKey

BNNSMPLZLMPJQX-UHFFFAOYSA-N

SMILES

C(N)(=O)C1=CC=C(OC2=CC=C3B(O)OCC3=C2)C=C1

4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-benzamide Usage And Synthesis

Uses

4-?[(1,?3-?Dihydro-?1-?hydroxy-?2,?1-?benzoxaborol-?5-?yl)?oxy]?-benzamide is used in the preparation of substituted benzoxaborole and related boron-containing small molecules as anti-inflammatory agents.

General Description

4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-benzamide, also known as Crisaborole Impurity 11, is an impurity of Crisaborole. Crisaborole topical is used to treat mild to moderate atopic dermatitis (eczema).