5-BROMO-2-METHYLPYRIDIN-3-AMINE Chemical Properties

Melting point:

108-109℃

Boiling point:

283.5±35.0 °C(Predicted)

Density 

1.593±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

crystalline solid

pka

4.53±0.20(Predicted)

color 

Off-white

InChI

InChI=1S/C6H7BrN2/c1-4-6(8)2-5(7)3-9-4/h2-3H,8H2,1H3

InChIKey

CBAXYISWNGGXOZ-UHFFFAOYSA-N

SMILES

C1(C)=NC=C(Br)C=C1N

Safety Information

Risk Statements 

41

Safety Statements 

26-39

HazardClass 

IRRITANT

HS Code 

2933399990

5-BROMO-2-METHYLPYRIDIN-3-AMINE Usage And Synthesis

Description

5-Bromo-2-methylpyridin-3-amine is also named as 3-Amino-5-bromo-2-methylpyridine. It can be converted to 5-bromo-2-methyl-3-pyridinol by diazotization with sodium nitrite in aqueous sulfuric acid. 5-Bromo-2-methyl-3-pyridinol can be used to make brominated dihydropyridines, which are substrates for the palladium catalyzed coupling, a process to produce compounds for the treatment of patients with disorders, such as central nervous system disorders.

Reference

G. Dull, J. Munoz, J. Genus, J. Moore, Hydroxybenzoate salts of metanicotine compounds, Patent US20060122239A1

Uses

3-Amino-5-bromo-2-methylpyridine (3ABMP) is a kind of biochemical reagent.

Synthesis

The general procedure for the synthesis of 2-methyl-3-amino-5-bromopyridine from 5-bromo-2-methyl-3-nitropyridine was as follows: 5-bromo-2-methyl-3-nitropyridine (13.8 g, 63.9 mmol) was dissolved in industrial methanol (330 mL) at 40 °C, followed by the addition of powdered iron (20 g) in batches to avoid agglomeration. Next, concentrated aqueous hydrochloric acid (5 mL) was added for elution. The resulting dark brown mixture was stirred vigorously under reflux conditions for 2 h. After completion of the reaction, it was cooled to room temperature and filtered through Celite (the filter cake was washed with 1 L of industrial methanol). The filtrate was concentrated under reduced pressure to remove the solvent, and the residue was dissolved in ethyl acetate (200 mL), the organic phase was washed with saturated aqueous sodium bicarbonate (200 mL), and dried with anhydrous magnesium sulfate. Finally, the solvent was removed under reduced pressure to afford the target product 5-bromo-2-methylpyridin-3-amine as an orange solid (10.7 g, 90% yield). The structure of the product was confirmed by 1HNMR (400 MHz, CDCl3, δ): 7.91 (s, 1H), 7.00 (s, 1H), 3.75 (br.s, 2H), 2.25 (s, 3H).

References

[1] Bergmeyer, et al. "Biochemical reagents." Methods of Enzymatic Analysis. Academic Press, 1965. 967-1037.

5-BROMO-2-METHYLPYRIDIN-3-AMINE(914358-73-9)Related Product Information

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• 3-BROMO-5-METHYLPYRIDIN-2-AMINE
• 5-BROMO-3-METHYLPYRIDIN-2-AMINE,5-Bromo-3-methylpyridin-2-amine ,98%
• 5-Bromo-6-methylpyridin-3-amine
• 5-Bromo-2-methylpyridine
• 3-BROMO-6-METHYLPYRIDIN-2-AMINE
• 3-Bromo-5-methylpyridin-4-amine
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• 5-Bromo-2-methylpyridin-4-amine
• 5-BROMO-N-METHYLPYRIDIN-2-AMINE
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• 6-BROMO-2-METHYLPYRIDIN-3-AMINE