2-Butyne-1,4-diol Chemical Properties

Melting point:

54 °C

Boiling point:

238 °C(lit.)

Density 

1.2

vapor pressure 

<0.1 mm Hg ( 55 °C)

refractive index 

1.4804

Flash point:

306 °F

storage temp. 

Store below +30°C.

solubility 

3740g/l

form 

Crystalline Platelets or Flakes

pka

12.72±0.10(Predicted)

color 

slightly brown

PH

4-7.5 (100g/l, H2O, 23℃)

Water Solubility 

3740 g/L (20 ºC)

BRN 

1071237

Exposure limits

ACGIH: TWA 0.1 ppm; STEL 0.3 ppm
OSHA: TWA 0.75 ppm; STEL 2 ppm
NIOSH: IDLH 20 ppm; TWA 0.016 ppm; Ceiling 0.1 ppm

Stability:

Stable. Highly flammable solid. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong acids, strong bases.

LogP

-0.73 at 25℃

CAS DataBase Reference

110-65-6(CAS DataBase Reference)

NIST Chemistry Reference

2-Butyne-1,4-diol(110-65-6)

EPA Substance Registry System

2-Butyne-1,4-diol (110-65-6)

Safety Information

Hazard Codes 

T,C

Risk Statements 

21-23/25-34-43-48/22

Safety Statements 

25-26-36/37/39-45-46

RIDADR 

UN 2716 6.1/PG 3

WGK Germany 

2

RTECS 

ES0525000

F 

23-10

Autoignition Temperature

410 °C

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29053980

Hazardous Substances Data

110-65-6(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 100 mg/kg

MSDS

• Language:English Provider:BOZ
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Butyne-1,4-diol Usage And Synthesis

Chemical Properties

yellow solid. Soluble in water, acidic solution, ethanol and acetone, slightly soluble in chloroform, insoluble in benzene and ether.

Uses

2-Butyne-1,4-diol is used as a precursor to prepare 1,4-butanediol, 2-butene-1,4-diol and mucochloric acid. It is also used in textile additives, corrosion inhibitors, plasticizers, synthetic resins and polyurethanes. It is an important raw material of vitamin B6. Further, it is used for brightening, preserving and inhibiting nickel plating. In addition, it is used in biological studies for nematocidal activity.

Application

Basic brightener in nickel electroplating baths, also an important intermediate for organic synthesis; corrosion inhibitor; defoliant ; polymerization accelerator; stabilizer for chlorinated hydrocarbons; cosolvent for paint and varnish removal.

Definition

ChEBI: 2-Butyne-1,4-diol is a butynediol that is but-2-yne substituted by hydroxy groups at positions 1 and 4. It is used to produce butanedioland butenediol, in metal plating andpickling baths, and in making the carbamateherbicide Barban (Carbyne).

General Description

1,4-butynediol appears as white to light-brown solid or brownish-yellow aqueous solution. Solid sinks and mixes with water. (USCG, 1999)

Air & Water Reactions

Water soluble.

Reactivity Profile

Pure 2-Butyne-1,4-diol is non-explosvie. Small amounts of certain impurities-alkali hydroxides, alkaline earth hydroxides, halides-may cause explosive decomposition upon distillation. 2-Butyne-1,4-diol should not be treated with basic catalysts in the absence of a solvent at room temperature, and its stability is less with elevated temperatures. In strong acids, contamination with mercury salts can also result in violent decomposition [NFPA 491M 1991].

Hazard

Toxic by ingestion. May explode on contamination with mercury salts, strong acids, and alkaline earth hydroxides and halides at high temperatures. May cause dermatitis.

Health Hazard

2-Butyne-1,4-diol exhibits moderate to hightoxicity in test animals. It is about 10 timesmore toxic than are the saturated C4 diols.The oral LD50 value in rats is 0.125 mL/kg.It causes irritation to the skin.

Fire Hazard

Noncombustible solid, flash point (open cup) 152°C (305.6°F). It is stable at room temperature. But the dry compound explodes in the presence of certain heavy metal salts, such as mercuric chloride. Heating with alkaline solution may result in an explosion.

Safety Profile

A poison by ingestion. A skin sensitizer upon long or repeated contact. Moderately explosive. When heated to decomposition it emits acrid smoke and fumes and may explode. Explosive reaction with traces of alkaltes, alkali earth hydroxides, halide salts, strong acids, mercury salts + strong acids. See also ACETYLENE COMTOUNDS.

Synthesis

2-butyne-1,4-diol is carried out by reaction under pressure of acetylene and an aqueous solution of formaldehyde, catalyzed by copper acetylide.

storage

2-Butyne-1,4-diol can be stored in steel,aluminum, nickel, glass, epoxy, and phenolicliner containers. Rubber hose may be usedfor transfer. Avoid contact with heavy metalsalt contaminants.

Purification Methods

Crystallise the diol from EtOAc. [Beilstein 1 IV 2687.]

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