Rifamycin Sodium
Rifamycin Sodium Basic information
- Product Name:
- Rifamycin Sodium
- Synonyms:
-
- RIFAMYCIN SODIUM
- RifaMycin, sodiuM salt (1:1)
- Rifamycin SV s
- Rifamycin SV sodium, >=900 IU/mg
- RIFAMPICIN SV SODIUM
- RIFAMYCIN SV-SODIUM
- RIFAMYCIN SV SODIUM SALT
- RIFAMYCIN SV SODIUM SALT HEXAHYDRATE
- CAS:
- 14897-39-3
- MF:
- C37H48NNaO12
- MW:
- 721.78
- EINECS:
- 238-965-7
- Product Categories:
-
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Peptide Synthesis/Antibiotics
- 14897-39-3
- Mol File:
- 14897-39-3.mol
Rifamycin Sodium Chemical Properties
- Melting point:
- >215°C (dec.)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- ethanol: soluble50mg/mL
- form
- powder
- color
- Dark Red
- Water Solubility
- Soluble in water, alcohol and dimethyl sulfoxide.
- Merck
- 13,8302
- InChIKey
- DJAAUWJRMPPGDA-HSBICLRHNA-N
MSDS
- Language:English Provider:SigmaAldrich
Rifamycin Sodium Usage And Synthesis
Chemical Properties
Dark Red Solid
Uses
Rifamycin SV Sodium (Rifaximin EP Impurity C) is a semi-synthetic antibiotic derived from Rifamycin S. (1) Antibacterial (2). Potency >900 units (dry basis).
Uses
Semi-synthetic antibiotic derived from Rifamycin S. Antibacterial. Potency >900 units (dry basis).
Biological Activity
Rifamycin SV inhibits selective (E. coli, B. subtilis) bacterial DNA-dependent RNA polymerase by binding to the polymerase β-subunit, a mechanism similar to rifabutin. It acts as a selective cytochrome P450 3A4 inducer. It is active against Gram-positive bacteria and is moderately active against Gram-negative organisms.
in vivo
Rifamycin (5 mg/day; s.c.; 3 days a week) sodium is effective in mice infected with M. tuberculosis, significantly reducing the number of viable bacteria in the body[4].
Rifamycin (12.5-25 mg/kg; peritoneal lavage) sodium can improve the survival rate of rats with experimental intraperitoneal infection and significantly reduce the number of intraperitoneal bacteria and adhesion formation[6].
Rifamycin (5-40 mg/kg; esophageal gavage; once a day, 5 days a week; 4 weeks) sodium shortens oral treatment duration in a mouse model of Mycobacterium ulcerans disease[8].
Rifamycin (0.1 mL; intraaural administration; twice daily; 10 days) sodium does not cause hearing loss in adult or weanling rats[9].
Rifamycin (1 mg i.v. bolus followed by 4 mg i.v. infusion; 70 min) sodium interferes with three major steps of Bile acid metabolism in rats with intravenous Sodium cholate (HY-N0324A) infusion, resulting in a significant decrease in bile acid uptake and excretion[10].
Rifamycin (10-160 mg/kg; s.c.; single dose) sodium is approximately 11 times less effective than Metronidazole (HY-B0318) in a mouse Bacteroides fragilis thigh infection model[11].
| Animal Model: | Male Wistar rats (weight 200-250 g), cecal ligation puncture (CLP)-induced intra-abdominal infection model[6] |
| Dosage: | 25 mg/kg, 12.5 mg/kg |
| Administration: | Peritoneal lavage |
| Result: | Improved survival from 50% in the control group to 91.7% in the 25 mg/kg group and 100% in the 12.5 mg/kg group. Significantly reduced adhesion formation. Showed a greater reduction in bacterial counts in peritoneal fluid (25 mg/kg). |
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Rifamycin Sodium(14897-39-3)Related Product Information
- Diclofenac sodium
- RIFAMYCIN SV
- Sodium sulfate
- Rifamycin O
- Sodium acetate
- Disodium phosphonomycin
- Sodium bicarbonate
- Sodium benzoate
- Sodium hydroxide
- Sodium chloride
- Sodium chlorite
- Rifampicin
- RIFAMYCIN
- RHENIUM(III) CHLORIDE
- RHENIUM(VII) OXIDE
- Riboflavin
- 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
- 1,3-DIHYDROXYNAPHTHALENE