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Estradiol hemihydrate

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Estradiol hemihydrate Basic information

Product Name:
Estradiol hemihydrate
Synonyms:
  • BETA-OESTRADIOL VETRANAL, 250 MG
  • beta-Estradiol semihydrate
  • Estra-1,3,5(10)-triene-3,17-diol(17b)-, hydrate (2:1)
  • (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol,hydrate
  • EESTRADIOL HEMIHYDRATE
  • Estradiol Hemihydrates
  • Estradiol hemihydrateQ: What is Estradiol hemihydrate Q: What is the CAS Number of Estradiol hemihydrate Q: What is the storage condition of Estradiol hemihydrate
  • Estradiol (1250008)
CAS:
35380-71-3
MF:
C18H24O2.H2O
MW:
290.4
EINECS:
631-198-2
Mol File:
35380-71-3.mol
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Estradiol hemihydrate Chemical Properties

storage temp. 
2-8°C
form 
powder
BRN 
1914275
InChI
InChI=1/C18H24O2.H2O/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20;/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3;1H2/t14?,15-,16?,17-,18+;/s3
InChIKey
QJNCGXGNKJUDEM-KEFFNRLXNA-N
SMILES
C12CC[C@@H](O)[C@@]1(C)CCC1C3C=CC(O)=CC=3CC[C@@]21[H].O |&1:3,5,19,r|
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Safety Information

Hazard Codes 
T
Risk Statements 
60-63-40-64
Safety Statements 
53-36/37-45
WGK Germany 
3
HS Code 
2937230000
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Estradiol hemihydrate Usage And Synthesis

Uses

Estradiol hemihydrate is a useful research chemical compound.

Uses

Estradiol hemihydrate (CAS# 35380-71-3) is a useful research chemical compound. It is used in methods of contraception using nomegestrol acetate and estradiol.

in vivo

Estradiol hemihydrate (1 nM, the hippocampal slices from FBN-ARO-KO mice) rescues long-term potentiation (LTP) amplitude[1]. Estradiol hemihydrate (0.0167 mg, implanted s.c., FBN-ARO-KO mice) rescues the molecular and functional deficits in FBN-ARO-KO mice[1].

Animal Model:FBN-ARO-KO Mice[2]
Dosage:1 nM
Administration:Treated for the hippocampal slices
Result:Rescued long-term potentiation (LTP) amplitude of both male and female mice.
Animal Model:FBN-ARO-KO Mice[2]
Dosage:0.0167 mg
Administration:Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation.
Result:Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain. Rescued the spatial learning and memory defects.

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