TROXACITABINE
TROXACITABINE Basic information
- Product Name:
- TROXACITABINE
- Synonyms:
-
- TROXACITABINE
- TROXACITABINE,2(1H)-PYRIMIDINONE, 4-AMINO-1-(2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL)-, (2S-CIS)-
- 4-Amino-1-[(2S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one
- (-)-Bch 204
- CS-150
- Lamivudine Impurity I (Troxacitabine)
- 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-1,2-dihydropyrimidin-2-one
- (-)-Occc
- CAS:
- 145918-75-8
- MF:
- C8H11N3O4
- MW:
- 213.19
- EINECS:
- 200-258-5
- Mol File:
- 145918-75-8.mol
TROXACITABINE Chemical Properties
- Melting point:
- 176-177°
- alpha
- D25 -38.33° (c = 0.43 in MeOH).
- Boiling point:
- 422.5±55.0 °C(Predicted)
- Density
- 1.71±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.83±0.10(Predicted)
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C8H11N3O4/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m0/s1
- InChIKey
- RXRGZNYSEHTMHC-BQBZGAKWSA-N
- SMILES
- C1(=O)N([C@@H]2CO[C@H](CO)O2)C=CC(N)=N1
TROXACITABINE Usage And Synthesis
Uses
Troxacitabine is a nucleoside analogue with potential anticancer activity. Troxacitabine have been studied in patients with refractory lymphoproliferative diseases.
Definition
ChEBI: Troxacitabine is a nucleobase-containing molecular entity and a carbohydrate derivative.
in vivo
Troxacitabine is highly active against the Panc-01 model, with TGI levels of 88.5% and 84.3% at the 10 and 25 mg/kg doses, respectively. The mean final tumor weights for animals given troxacitabine are also significantly smaller compared with vehicle controls. Troxacitabine has less activity against the MiaPaCa model[3]. Troxacitabine is very effective in human RCC tumor xenograft models, including CAM-i, A498, RXF-393, and SN12C carcinomas. Very good responses are ob served in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days[2].
TROXACITABINESupplier
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- 021-56491756 13512199871
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- 010-56205725
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- Tel
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TROXACITABINE(145918-75-8)Related Product Information
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- Aids004768
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- 4-(HYDROXYMETHYL)BENZONITRILE
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- Lamivudine Impurity 9
- Lamivudine impurity 6
- (1r,2s,5r)-2-Isopropyl-5-Methylcyclohexyl-5-Hydroxy-1,3oxathiolane-2-Carboxylate
- Gemcitabine
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- Lamivudine EP Impurity B