Azaphen hydrochloride Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Solid

Safety Information

Toxicity

LD50 orl-rat: 1 g/kg ZPPLBF 114,787,75

Azaphen hydrochloride Usage And Synthesis

Uses

Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin. IC50 Value: Target: SSRIs Pipofezine is a tricyclic antidepressant (TCA) approved in Russia for the treatment of depression.

Safety Profile

Poison by ingestion, intravenous,and subcutaneous routes. When heated to decompositionit emits very toxic fumes of HCl and NOx. Anantidepressant.

References

[1] Domestic antidepressants. 1. Azaphen By Andreeva, N. I.; Asnina, V. V.; Liberman, S. S. From Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal) (2000), 34(5), 237-241.
[2] Shinaev NN, Akzhigitov RG. Azaphen: a return to clinical practice.Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(10):55-6. PMID:16281382
[3] Ignatowicz L, Ignatowicz R, Wdowiak MW, Jaremko A. Azaphen in the treatment of enuresis in children.Psychiatr Pol. 1977 Jan-Feb;11(1):29-33. PMID:557800
[4] Liberman SS, Sharova SA. A comparison of the effect of the tricyclic antidepressants azaphen and imizin on the gastrointestinal tracts of experimental animals.Farmakol Toksikol. 1975 Jan-Feb;38(1):29-32. PMID:1112390
[5] Misurec J, Náhunek K, Kamenická V, Chmelar M. Proceedings: Influence of azaphen, a new antidepressive drug, on the human EEG. Act Nerv Super (Praha). 1974;16(4):245-6. PMID:4450998

Azaphen hydrochloride(24853-80-3)Related Product Information

• DIAZOXIDE
• Methanol
• Kresoxim-methyl
• Paraquat dichloride
• Topotecan hydrochloride
• Methyl acetate
• 5-Azacytidine
• Methyl acrylate
• Basic Violet 1
• Acetonitrile
• Phenazine methosulfate
• Methylparaben
• Phenothiazine
• Methyl
• Dihydrochloride
• 1-(6-Pyridazinyl)piperazine
• 3-AMINO-6-METHOXYPYRIDAZINE
• 3-PIPERAZIN-1-YL-PYRIDAZINE DIHYDROCHLORIDE