BAMIFYLLINE Chemical Properties

Melting point:

80-80.5°

Boiling point:

619.0±65.0 °C(Predicted)

Density 

1.25

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly)

pka

14.73±0.10(Predicted)

form 

Solid

color 

White to Pale Brown

Stability:

Hygroscopic

BAMIFYLLINE Usage And Synthesis

Originator

Bamifylline,ZYF Pharm Chemical

Uses

Bronchodilator.

Uses

Bamifylline is a drug of the xanthine chemical class which acts as a selective adenosine A1 receptor antagonist.

Definition

ChEBI: Bamifylline is an oxopurine.

Manufacturing Process

A mixture of 100 kg of 8-benzyltheophilline, 36 L of N-ethylethanolamine, 300 L of 1,2-dichlorethane and 71 kg of sodium carbonate was refluxed for 24 hours. Then 36 L of N-ethylethanolamine was added and the reaction mixture was refluxed. After cooling to the mixture was added the water and hydrochloric acid. The organic phase was extracted with hydrochloric acid. The acidic phase was neutralized with sodium carbonate and the 7-(N-ethyl-N-β- hydroxyethylaminoethyl)-8-benzyltheophilline was extracted with dichloromethane. The solvent was evaporated and the free base of 7-(N-ethyl- N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was dissolved in methanol. Hydrochloride of 7-(N-ethyl-N-β-hydroxyethylaminoethyl)-8-benzyltheophilline was obtained by addition to the solution the hydrochloric acid; yield 81%, melting point 185-186°C.

Therapeutic Function

Bronchodilator, Coronary vasodilator

BAMIFYLLINE(2016-63-9)Related Product Information

• Theophylline
• etamiphyllin
• BAMIFYLLINE
• 8-BENZYLTHEOPHYLLINE
• dimethazan
• AC 119
• 1-Methylcaffeine
• bamifylline hydrochloride ,BAMIFYLLINE HCL
• 7-(2-aminoethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione