Piroheptine
Piroheptine Basic information
- Product Name:
- Piroheptine
- Synonyms:
-
- piroheptine hydrochloride
- Pyrrolidine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methyl-, hydrochloride (8CI, 9CI)
- Trimol
- Piroheptine HCl
- CAS:
- 16378-22-6
- MF:
- C22H25N.ClH
- MW:
- 339.907
- Mol File:
- 16378-22-6.mol
Piroheptine Chemical Properties
- Melting point:
- 250-253°
Piroheptine Usage And Synthesis
Uses
Piroheptine hydrochloride is an anticholinergic agent to inhibit dopamine uptake. Piroheptine hydrochloride prevents loss of striatal dopamine induced by MPTP (HY-15608). Piroheptine hydrochloride can be used for research in Parkinson[1].
Definition
ChEBI: Piroheptine hydrochloride is the hydrochloride salt of piroheptine. It has a role as an antiparkinson drug and a muscarinic antagonist. It contains a piroheptine(1+).
in vivo
Piroheptine hydrochloride (20 mg/kg; ip; singel dose, 30 min before MPTP injection) suppresses neurotoxicity of MPTP in mice model[1].
| Animal Model: | Male 8-week-old C57BL/6J mice (20-30 g)[1] |
| Dosage: | 20 mg/kg |
| Administration: | IP; 30 min before MPTP injection (10 mg/kg; 4 times with 1 h interval) |
| Result: | Prevented loss of striatal dopamine. |
References
[1] Saitoh T. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl. J Neurol Sci. 1988 Feb;83(2-3):161-6. DOI:10.1016/0022-510x(88)90065-2
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