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Fmoc-N-Me-Tyr(tBu)-OH

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Fmoc-N-Me-Tyr(tBu)-OH Basic information

Product Name:
Fmoc-N-Me-Tyr(tBu)-OH
Synonyms:
  • (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(4-tert-butoxyphenyl)propanoic acid
  • O-(tert-Butyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-tyrosine
  • FMOC-N-METHYL-O-TERT-BUTYL-L-TYROSINE
  • N-FMoc-N-Methyl-O-tert-butyl-L-tyrosine
  • fMoc-N-Me-tyr(tbu)-oh
  • FMOC-L-METYR(TBU)-OH
  • FMOC-N-ALPHA-METHYL-O-T-BUTYL-L-TYROSINE
  • FMOC-METYR(TBU)-OH
CAS:
133373-24-7
MF:
C29H31NO5
MW:
473.56
Product Categories:
  • amino acids
  • Tyrosine [Tyr, Y]
  • N-Methyl Amino Acids
  • Fmoc-Amino acid series
Mol File:
133373-24-7.mol
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Fmoc-N-Me-Tyr(tBu)-OH Chemical Properties

Melting point:
186-191°C
Boiling point:
638.9±55.0 °C(Predicted)
Density 
1.208
storage temp. 
2-8°C
pka
2.98±0.10(Predicted)
optical activity
[α]22/D -49.0°, c = 0.5% in DMF
InChIKey
WTLSDEYZKFJXFT-SANMLTNESA-N
SMILES
C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C
CAS DataBase Reference
133373-24-7(CAS DataBase Reference)
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Safety Information

WGK Germany 
3
HS Code 
2924 29 70
HazardClass 
IRRITANT
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Fmoc-N-Me-Tyr(tBu)-OH Usage And Synthesis

Chemical Properties

White powder

General Description

Fmoc-N-Me-Tyr(tBu)-OH is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a very important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

(9H-Fluoren-9-yl)methyl carbonochloridate could be used as the starting material to synthesize Fmoc-N-Me-Tyr(tBu)-OH.

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