INDOMETHACIN SODIUM
INDOMETHACIN SODIUM Basic information
- Product Name:
- INDOMETHACIN SODIUM
- Synonyms:
-
- 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-aceticacisodiumsalt
- 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-aceticacisodiumsalt
- osmosin
- sodium1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetate
- sodiumindomethacin
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid sodium salt
- IndoMetacine sodiuM
- 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, sodiuM salt
- CAS:
- 7681-54-1
- MF:
- C19H15ClNNaO4
- MW:
- 379.77
- EINECS:
- 231-670-4
- Mol File:
- 7681-54-1.mol
INDOMETHACIN SODIUM Chemical Properties
- storage temp.
- Sealed in dry,Room Temperature
- form
- Powder
- InChI
- InChI=1S/C19H16ClNO4.Na/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12;/h3-9H,10H2,1-2H3,(H,22,23);/q;+1/p-1
- InChIKey
- JMHRGKDWGWORNU-UHFFFAOYSA-M
- SMILES
- C12C=CC(OC)=CC=1C(=C(C)N2C(=O)C1C=CC(Cl)=CC=1)CC([O-])=O.[Na+]
INDOMETHACIN SODIUM Usage And Synthesis
Description
Indomethacin sodium is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research.
Uses
Anti-inflammatory.
brand name
Indocin (Ovation).
in vivo
Indomethacin (Indometacin) sodium (0.01-10 mg/kg; p.o.; for 3 hours; male Sprague-Dawley rats) induces paw oedema and hyperalgesmeasurement dose-dependently reversed carrageenan-induced hyperalgesia[1].
Indomethacin (Indometacin) sodium (10 mg/mL; p.o.; daily, for 29 days; male C57BL/6J mice) inhibits tumor growth in vivo[2].
| Animal Model: | Male Sprague-Dawley rats[1] |
| Dosage: | 0.01-10 mg/kg |
| Administration: | Oral administration; for 3 hours |
| Result: | Inhibited the carrageenan-induced rat paw oedema (ED50=2.0?mg/kg) and hyperalgesia (ED50=1.5?mg/kg) in a dose-dependent manner. |
| Animal Model: | Male C57BL/6J mice[2] |
| Dosage: | 10 mg/mL |
| Administration: | Oral administration; daily, for 29 days |
| Result: | Delayed the onset of tumor growth and the initial growth rate of the footpad tumors. |
IC 50
COX-1: IC50 = 0.1 μM (sheep); Cox-1: IC50 = 1.67 μM (human);
COX-2: IC50 = 6 μM (sheep); Cox-2: IC50 = 24.6 μM (human)
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