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Ginkgolide C

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Ginkgolide C Basic information

Product Name:
Ginkgolide C
Synonyms:
  • GINKGOLIDE C
  • 1,7-DIHYDROXY-GINKGOLIDE A
  • (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
  • Gingkolide C
  • bn52022
  • GinkgolideA,1,7-dihydroxy-, (1α,7β)-
  • CGinkgolid
  • Ginkgolide C, 98%, from Ginkgo biloba L.
CAS:
15291-76-6
MF:
C20H24O11
MW:
440.4
Product Categories:
  • Pharmaceuticals
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Intermediates & Fine Chemicals
  • Saponins
Mol File:
15291-76-6.mol
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Ginkgolide C Chemical Properties

Melting point:
>3000 (dec)
alpha 
D24 -14.7° (c = 1 in ethanol)
Boiling point:
813.8±65.0 °C(Predicted)
Density 
1.72±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Heated)
form 
Solid
pka
10.88±0.70(Predicted)
color 
White to Off-White
InChIKey
AMOGMTLMADGEOQ-WCHJOOGENA-N
LogP
1.719 (est)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
F 
10-21
HS Code 
29322090
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Ginkgolide C Usage And Synthesis

Description

Ginkgolide C is a flavone first extracted from G. biloba leaves with multiple reported biological functions. It has been identified as a selective platelet activating factor receptor antagonist (IC50 = 37.6 μM). Ginkgolide C has also been shown to increase lipolysis and to inhibit adipogenesis in adipocytes via the activated AMPK pathway.

Chemical Properties

Crystalline Solid

Uses

Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists.

Uses

Reference compound for PAF receptors in biological systems.

IC 50

AMPK; MMP-9; Sirtuin

References

[1] PIERRE BRAQUET. Recent progress in ginkgolide research[J]. Medicinal Research Reviews, 1991, 11 3: 295-355. DOI: 10.1002/med.2610110303
[2] CHIAN-JIUN LIOU. Ginkgolide C Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway.[J]. Evidence-based Complementary and Alternative Medicine, 2015: 298635. DOI: 10.1155/2015/298635

Ginkgolide CSupplier

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