4,6-Dimethyl-2-hydroxypyrimidine Chemical Properties

Melting point:

201-205 °C

Boiling point:

230.92°C (rough estimate)

Density 

1.1683 (rough estimate)

refractive index 

1.5378 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

10.34±0.10(Predicted)

form 

Solid

color 

Off-White to Pale Yellow

CAS DataBase Reference

108-79-2(CAS DataBase Reference)

NIST Chemistry Reference

4,6-Dimethyl-2-pyrimidinol(108-79-2)

EPA Substance Registry System

2(1H)-Pyrimidinone, 4,6-dimethyl- (108-79-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-45-37-28

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29335990

MSDS

• Language:English Provider:2-Hydroxy-4,6-dimethylpyrimidine
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4,6-Dimethyl-2-hydroxypyrimidine Usage And Synthesis

Chemical Properties

Off-white, light yellow to pink crystalline powder

Uses

4,6-Dimethyl-2-hydroxypyrimidine is a component of Nicarbazine (N394530), a coccidiostat, which is an antiprotozoal agent that acts upon Coccidia parasites.

Synthesis

IM06: Synthesis of 4,6-dimethylpyrimidin-2-one Step 1: Urea (20.0 g, 333.3 mmol) and acetylacetone (33.3 g, 333.3 mmol) were dissolved in ethanol (166 mL), followed by the slow addition of concentrated aqueous hydrochloric acid solution (45 mL). The reaction mixture was stirred at 80 °C for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, the precipitate was collected by filtration and washed with cold ethanol to afford 4,6-dimethylpyrimidin-2-ol as a colorless solid (40 g, 97% yield). The product was characterized by 1H NMR (DMSO-d6, 400 MHz): δ 7.35 (1H, s), 2.43 (6H, s).

Purification Methods

Crystallise the pyrimidine from absolute EtOH (charcoal). [Beilstein 24/2 V 138.]

References

[1] Patent: US2013/5743, 2013, A1. Location in patent: Page/Page column 12
[2] Patent: WO2013/4617, 2013, A1. Location in patent: Page/Page column 30
[3] European Journal of Inorganic Chemistry, 2018, vol. 2018, # 23, p. 2695 - 2701

4,6-Dimethyl-2-hydroxypyrimidine(108-79-2)Related Product Information

• Dimethicone
• 4-Cyanophenol
• CHLOROPHOSPHONAZO III
• Dimethyl phthalate
• Dimethyl carbonate
• N,N-Dimethylformamide
• Dimethyl fumarate
• Dimethyl ether
• Dimethyl sulfoxide
• Dimethyl sulfate
• Dacthal
• ETHANE
• 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL
• 2-Hydroxypyrimidine
• Dimethyl disulfide
• Poly(dimethylsiloxane)
• 4,6-Dihydroxypyrimidine
• 4,6-DIMETHYL-2-HYDROXYPYRIMIDINE HYDROCHLORIDE,4,6-DIMETHYL-2-HYDROXYPYRIMIDINE HYDROCHLORIDE 97+%