MEN 935
MEN 935 Basic information
- Product Name:
- MEN 935
- Synonyms:
-
- MEN 935
- 3-[3-[(2-hydroxy-3-naphthalen-1-yloxypropyl)amino]-3-methylbutyl]-1H-benzimidazol-2-one
- CAS:
- 75708-29-1
- MF:
- C25H29N3O3.ClH.H2O
- MW:
- 473.998
- Mol File:
- 75708-29-1.mol
MEN 935 Usage And Synthesis
Originator
Adimolol hydrochloride ,ZYF Pharm Chemical
Uses
Adimolol is an antihypertensive agent and a β-adrenoceptor blocker.
Manufacturing Process
A mixture consisting of 3 g of 1-(3-amino-3,3-dimethyl-n-propyl)
benzimidazolidinone-2, 3.3 g of 1-[naphthyl-(1)-oxyl]propylene-(2,3)-epoxide
and 12 ml of 98% ethanol were refluxed for three hours. Thereafter, the
ethanol was distilled off, the residue was taken up in some methanol, and the
solution was acidified with 1 N hydrochloric acid and then extracted with ethyl
acetate. The ethyl acetate was distilled out of the extract solution, and ether
and some water were added to the residue, whereupon a crystalline substance
separated out. The product was recrystallized from ethanol, yielding 60% of
theory of ()-1-(3-((2-hydroxy-3-(1-naphthyloxy)propyl)amino)-3-
methylbutyl)-2-benzimidazolinone, which had a melting point of 161°C.
In practice it is usually used as hydrochloride.
Therapeutic Function
Alpa- and Beta-adrenergic blocker
MEN 935Supplier
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- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
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- 021-58432009 400-005-6266
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- 15522676233
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- 15002134094
- marketing@targetmol.cn
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- +8613564774135
- zijue.cai@tsbiochem.com