cis-1,4-Cyclohexanedicarboxybic acid Chemical Properties

Melting point:

168 °C

Boiling point:

384.1±35.0 °C(Predicted)

Density 

1.3200

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Ethanol,Ether,Chloroform,Methanol

form 

powder to crystal

pka

4.51±0.25(Predicted)

color 

White to Almost white

CAS DataBase Reference

619-81-8(CAS DataBase Reference)

NIST Chemistry Reference

cis-Hexahydroterephthalic acid(619-81-8)

Safety Information

HS Code 

29172090

cis-1,4-Cyclohexanedicarboxybic acid Usage And Synthesis

Definition

ChEBI: 1,4-cyclohexanedicarboxylic acid is a dicarboxylic acid that is cyclohexane substituted by carboxy groups at positions 1 and 4.

Synthesis

The general procedure for synthesizing cis-1,4-cyclohexanedicarboxylic acid from terephthalic acid was as follows: 200 g of terephthalic acid, 15 g of the Pd-Pt/C catalyst of Examples 1 to 14 and 1000 g of water were added to an autoclave, and stirring was initiated. The reaction system was first purged with nitrogen three times, followed by hydrogen replacement three times. The hydrogen pressure was adjusted to 4 MPa, the reaction temperature was maintained at 200°C, and hydrogen was continuously supplied under this condition for 3 hours. At the end of the reaction, the catalyst was removed by filtration while hot. The filtrate was cooled and filtered again to collect the filter cake. The filter cake was dried at 120°C to obtain the solid product. The solid product was analyzed by liquid chromatography to determine the contents of 1,4-cyclohexanedicarboxylic acid and trans-1,4-cyclohexanedicarboxylic acid therein, from which the yield of 1,4-cyclohexanedicarboxylic acid and the selectivity of trans-1,4-cyclohexanedicarboxylic acid were calculated, and the specific results are listed in Table 2.

References

[1] Patent: CN103769089, 2016, B. Location in patent: Paragraph 0029; 0030
[2] RSC Advances, 2017, vol. 7, # 30, p. 18178 - 18188
[3] Patent: CN105237341, 2016, A. Location in patent: Paragraph 0014
[4] Patent: KR2017/36493, 2017, A. Location in patent: Paragraph 0057; 0058; 0059
[5] Patent: KR2018/35585, 2018, A. Location in patent: Paragraph 0117-0121; 0145; 0146

cis-1,4-Cyclohexanedicarboxybic acid(619-81-8)Related Product Information

• Dicyclohexylamine
• Cyclohexanone
• Bis(cyclohexanone)oxaldihydrazone
• 2,5-PYRIDINEDICARBOXYLIC ACID
• N,N-Dimethylcyclohexylamine
• cis-Hexahydrophthalic acid
• CIS-CYCLOPENTANE-1,2-DICARBOXYLIC ACID
• CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
• cis-1,3-cyclohexanedicarboxylic acid
• (1S,3R)-cyclopentane-1,3-dicarboxylic acid
• CIS-2-PHENYL-1,3-DIOXAN-5-OL
• CIS-1,4-DIACETOXY-2-BUTENE
• CIS-1,4-DIMETHYL CYCLOHEXANEDICARBOXYLATE
• Dimethyl 1,4-cyclohexanedicarboxylate
• Bicyclo[2.2.2]Octane-1,4-Dicarboxylic Acid
• dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate
• DIETHYL 2,5-DIOXOBICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLATE
• DIMETHYL 1,4-CUBANEDICARBOXYLATE