CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE Basic information
- Product Name:
- CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
- Synonyms:
-
- 2-Cyano-3-ethoxy-2-proenoicacidethylester
- 3-Isobenzofuranedione,hexahydro-,cis-1
- cis-cyclohexane-1,2-dicarboxylicacidanhydride
- Hexahydro-2-benzofuran-1,3-dione
- (3aS)-3aα,4,5,6,7,7aα-Hexahydroisobenzofuran-1,3-dione
- (3aα,7aα)-Octahydroisobenzofuran-1,3-dione
- 3aα,4,5,6,7,7aα-Hexahydroisobenzofuran-1,3-dione
- (1R)-Cyclohexane-1β,2α-dicarboxylic anhydride
- CAS:
- 13149-00-3
- MF:
- C8H10O3
- MW:
- 154.16
- EINECS:
- 236-086-3
- Product Categories:
-
- Pharmaceutical Intermediates
- Mol File:
- 13149-00-3.mol
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CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE Chemical Properties
- Melting point:
- 32-34 °C(lit.)
- Boiling point:
- 158 °C17 mm Hg(lit.)
- Density
- 1.23
- refractive index
- 1.4750 (estimate)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Crystalline Low Melting Solid
- color
- White to almost white
- Sensitive
- Moisture Sensitive
- BRN
- 83214
- Stability:
- Moisture Sensitive
- CAS DataBase Reference
- 13149-00-3(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 41-42/43
- Safety Statements
- 23-24-26-37/39
- WGK Germany
- 1
- F
- 10-21
- HS Code
- 29420000
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
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CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE Usage And Synthesis
Chemical Properties
white to almost white cryst. low melting solid
Uses
(3aR,7aS)-rel-Hexahydro-1,3-isobenzofurandione is a reagent used in the synthesis of Pregabalin (P704800), a GABA analogue used as an anticonvulsant. Also used to prepare P2X7 receptor antagonists.
Purification Methods
It has been obtained by heating the trans-acid or anhydride at 200o. Crystallise it from *C6H6/Et2O or distil it. [Kohler & Jansen J Am Chem Soc 60 2145 1938, Abell J Org Chem 22 769 1957, Beilstein 17 II 452, 17 III/IV 5931.]
CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE Preparation Products And Raw materials
Raw materials
CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDESupplier
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Alfa Aesar
- Tel
- 400-6106006
- saleschina@alfa-asia.com
TCI (Shanghai) Development Co., Ltd.
- Tel
- 021-67121386
- Sales-CN@TCIchemicals.com
Beijing HwrkChemical Technology Co., Ltd
- Tel
- 010-89508211 18501085097
- sales.bj@hwrkchemical.com
Energy Chemical
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
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CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE(13149-00-3)Related Product Information
- Dimethyl cyclohexane-1,2-dicarboxylate
- cis-1,4-Cyclohexanedicarboxybic acid
- CIS-1,4-DIMETHYL CYCLOHEXANEDICARBOXYLATE
- cis-1,2-Diaminocyclohexane
- CIS-1,4-DIACETOXY-2-BUTENE
- CIS-2-PHENYL-1,3-DIOXAN-5-OL
- (1S,3R)-cyclopentane-1,3-dicarboxylic acid
- cis-1,3-cyclohexanedicarboxylic acid
- CIS-CYCLOPENTANE-1,2-DICARBOXYLIC ACID
- cis-Hexahydrophthalic acid
- ETHYLENE OXIDE
- Phthalic anhydride
- cis-1,2,3,6-Tetrahydrophthalic anhydride
- Methyl tetrahydrophthalic anhydride
- Cobalt sulfate
- Levulinic acid
- EXO-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC ANHYDRIDE
- ENDO-BICYCLO[2.2.2]OCT-5-ENE-2,3-DICARBOXYLIC ANHYDRIDE