Raxofelast
Raxofelast Basic information
- Product Name:
- Raxofelast
- Synonyms:
-
- Raxofelast
- IRFI-016
- 2-(5-acetoxy-4,6,7-trimethyl-2,3-dihydrobenzofuran-2-yl)acetic acid
- 2-Benzofuranacetic acid, 5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl-
- CAS:
- 128232-14-4
- MF:
- C15H18O5
- MW:
- 278.302
- Mol File:
- 128232-14-4.mol
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Raxofelast Usage And Synthesis
Uses
Raxofelast (IRFI-016) is an antioxidant agent in various models of ischemia-reperfusion injury. Raxofelast has antiproliferative activity in H2O2-stimulated rat aortic smooth muscle cells. Raxofelast attenuates the activation of mitogen-activating protein kinase (MAPK), ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression[1].
References
[1] Kyung-Hye Lee, et al. Antiproliferative mechanisms of raxofelast (IRFI-016) in H2O2-stimulated rat aortic smooth muscle cells. Eur J Pharmacol. 2004, 484, 2-3. DOI:10.1016/j.ejphar.2003.11.012
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