3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate Chemical Properties

Melting point:

197.0 to 201.0 °C

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

color 

White to Almost white

Safety Information

HS Code 

2925.29.9000

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate Usage And Synthesis

Chemical Properties

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate Appearance white to almost white powder to crystals, melting point 199 °C, storage 2-8 °C.

Uses

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate is an organic synthetic material or pharmaceutical intermediate compound that can be used in the preparation of N-phenyl-2-pyrimidinamine derivatives and in the synthesis of nilotinib and its salts. Nilotinib is a tyrosine kinase inhibitor used for the treatment of drug-resistant chronic myelogenous leukemia (CML), and in particular, for the treatment of chronic phase and accelerated phase Philadelphia chromosome positive chronic myeloid leukemia (CML) in adult patients whose disease has progressed on or who cannot tolerate other therapies that included imatinib. Nilotinib is administrated as a hydrochloride salt in the form of capsules that are marketed in the USA and the EU under the name Tasigna?.

3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate(641569-96-2)Related Product Information

• N,N-Dimethyl-1,4-phenylenediamine
• Hexamethyleneimine
• Tris(hydroxymethyl)aminomethane
• Ethyl 4-hydroxybenzoate,sodium salt
• Glycine
• Tris(trimethylsilyl)phosphate
• Ethyl benzoate
• Ethyl acetate
• Ethylparaben
• Nilotinib Impurity 7
• Nilotinib genotoxic impurity 3
• Nilotinib Impurity 1
• Nilotinib Impurity 20
• 3-Amino-4-methylbenzoic acid
• Nilotinib Impurity 28
• Nilotinib impurity 3
• 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide
• Methyl methacrylate