4-(Pyrimidin-2-yl)benzoic acid Chemical Properties

Melting point:

238 °C

Boiling point:

301.5±34.0 °C(Predicted)

Density 

1.302±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

3.67±0.10(Predicted)

Appearance

Off-white to light brown Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Hazard Note 

Harmful

HS Code 

2933599590

4-(Pyrimidin-2-yl)benzoic acid Usage And Synthesis

Uses

4-Pyrimidin-2-yl-benzoic acid (cas# 199678-12-1) is a useful reactant for the synthesis of alkylimino-quinolinyl isoindolones.

Synthesis

In a 250 mL round bottom flask, the compound obtained in the previous step (4.4 g, 20.54 mmol, 1.00 eq.), sodium hydroxide (2.4 g, 60.00 mmol, 2.92 eq.), and methanol (50 mL) were mixed. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted to 7 with 1 M hydrochloric acid. the precipitated solid was collected by filtration to give 3.15 g of light yellow solid product in 77% yield.

References

[1] Patent: US2016/237043, 2016, A1. Location in patent: Paragraph 0553; 0555

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