Basic information Safety Supplier Related

KIFUNENSINE

Basic information Safety Supplier Related

KIFUNENSINE Basic information

Product Name:
KIFUNENSINE
Synonyms:
  • Kifunensine, Kitasatosporia kifunense - CAS 109944-15-2 - Calbiochem
  • Kifunensine, (+)- - FR 900494
  • FR 900494, Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione
  • (5R,8aS)-1,5,6,7,8,8a-Hexahydro-6β,7α,8α-trihydroxy-5α-(hydroxymethyl)imidazo[1,2-a]pyridine-2,3-dione
  • (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
  • [5R-(5α,6β,7α,8α,8aα)]-
  • Kifunensine min. 99%
  • FR 900494
CAS:
109944-15-2
MF:
C8H12N2O6
MW:
232.19
Product Categories:
  • Antibiotics
  • All Inhibitors
  • Glycosidase Inhibitors
  • Inhibitors
Mol File:
109944-15-2.mol
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KIFUNENSINE Chemical Properties

Melting point:
>280°C
Density 
1.85±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
water, double-distilled: soluble50MM
form 
White solid
pka
9.61±0.70(Predicted)
Stability:
Desiccate and Store at -20°C
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Safety Information

WGK Germany 
3
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KIFUNENSINE Usage And Synthesis

Chemical Properties

White Powder

Uses

Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme

Biological Activity

Inhibitor of class I α -mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α -1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with K i values of 130 and 23 nM respectively.

KIFUNENSINESupplier

J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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3B Pharmachem (Wuhan) International Co.,Ltd.
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Chemsky(shanghai)International Co.,Ltd.
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Shanghai T&W Pharmaceutical Co., Ltd.
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Shanghai Kewel Chemical Co., Ltd.
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021-64609169-
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kewelchemexp@yahoo.com