5-BROMO-2-CHLORO-3-METHOXYPYRIDINE Chemical Properties

Melting point:

68-72°C

Boiling point:

245.6±35.0 °C(Predicted)

Density 

1.650±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

solid

pka

-3.02±0.10(Predicted)

color 

White to off-white

InChI

InChI=1S/C6H5BrClNO/c1-10-5-2-4(7)3-9-6(5)8/h2-3H,1H3

InChIKey

GFJMOZYIDADKLJ-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=C(Br)C=C1OC

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-41-25

Safety Statements 

26-39-45

RIDADR 

2811

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

2933399990

5-BROMO-2-CHLORO-3-METHOXYPYRIDINE Usage And Synthesis

Synthesis

Step 3: Synthesis of 5-bromo-2-chloro-3-methoxypyridine 5-Bromo-2-chloro-3-hydroxypyridine (1.88 g, 9 mmol), iodomethane (1.42 g, 10 mmol) and potassium carbonate (K2CO3, 2.76 g, 20 mmol) were dissolved in acetonitrile. The reaction mixture was stirred at 80 °C for 4 hours. After completion of the reaction, the solvent was removed by evaporation and the residue was dissolved in dichloromethane (CH2Cl2). The resulting solution was washed with water and the organic phase was dried over anhydrous sodium sulfate and concentrated. Finally, the target product 5-bromo-2-chloro-3-methoxypyridine (1.62 g, 81% yield) was purified by silica gel column chromatography. Mass spectrum (ESI) m/z: 223.9 [M + 1].

References

[1] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0148
[2] Patent: US2002/19388, 2002, A1
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3627 - 3644
[4] Patent: EP1147112, 2003, B1. Location in patent: Page/Page column 35
[5] Patent: US2003/225268, 2003, A1. Location in patent: Page 31-32

5-BROMO-2-CHLORO-3-METHOXYPYRIDINE(286947-03-3)Related Product Information

• 2-Chloro-3-methoxypyridine
• 5-BROMO-2-CHLORO-3-METHOXYPYRIDINE
• 3-Bromo-5-methylpyridine
• 3-Bromo-5-hydroxypyridine
• 5-BROMO-2-CHLORO-PYRIDIN-3-OL