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CAY10505

Basic information Safety Supplier Related

CAY10505 Basic information

Product Name:
CAY10505
Synonyms:
  • CAY10505
  • (5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
  • (E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
  • CAY10505 ( 5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
  • CAY10505, >=98%
  • 2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-, (5E)-
  • CAY10505 USP/EP/BP
  • CAY10505 CAY-10505
CAS:
1218777-13-9
MF:
C14H8FNO3S
MW:
289.28
Product Categories:
  • Akt
  • mTOR
  • PI3K/Akt/mTOR
  • Inhibitors
  • PI3K
Mol File:
1218777-13-9.mol
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CAY10505 Chemical Properties

Density 
1.466
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥14.45 mg/mL in DMSO
form 
solid
pka
7.21±0.20(Predicted)
color 
Light yellow to yellow
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CAY10505 Usage And Synthesis

Uses

CAY10505 is a phosphoinositide 3-kinase gamma (PI3Kγ) specific inhibitor and improves hypertension-associated vascular endothelial dysfunction.

Biological Activity

cay10505 is a potent and selective pi3kγ inhibitor (ic50= 30 nm)pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.in neurons treated with 3.5 μm ba, 200 nm cay10505 partially reduced the baicalein-induced akt phosphorylation. [1]in hypertensive rats, cay10505 at 0.6 mg.kg-1 p.o. exhibited the following effects 1) effectively reduced mabp; 2) significantly ameliorated vascular endothelium dysfunction in hypertensive rats in combination of doca; 3) prominently increased serum nitrite and/or nitrate concentrations.4) prevented hypertension-induced attenuation of ach-induced endothelium-dependent relaxation.[2]

References

[1] tyagi s, sharma s, budhiraja rd. effect of phosphatidylinositol 3-kinase-γ inhibitor cay10505 in hypertension, and its associated vascular endothelium dysfunction in rats. can j physiol pharmacol. 2012 jul;90(7):881-5.
[2] sun yy, lin sh, lin hc et al. cell type-specific dependency on the pi3k/akt signaling pathway for the endogenous epo and vegf induction by baicalein in neurons versus astrocytes. plos one. 2013 jul 19;8(7):e69019.

CAY10505Supplier

Jinan Trio PharmaTech Co., Ltd.
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+86 (531) 88811783
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Dalian Meilun Biotech Co., Ltd.
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NCE Biomedical Co.,Ltd.
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Haoyuan Chemexpress Co., Ltd.
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-400-6206333 18521732826
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