ANTI-MBD4
ANTI-MBD4 Basic information
- Product Name:
- ANTI-MBD4
- Synonyms:
-
- Anti-Methyl-CpG-binding domain protein 4 antibody produced in rabbit
- Anti-MBD4 antibody produced in rabbit
- Anti-Methyl-CpG-binding endonuclease 1 antibody produced in rabbit
- Anti-Methyl-CpG-binding protein MBD4 antibody produced in rabbit
- Anti-Mismatch-specific DNA N-glycosylase antibody produced in rabbit
- ANTI-METHYL-CPG-BINDING DOMAIN 4 (268-282, 337-352) RABBIT PAB
- ANTI-METHYL-CPG-BINDING DOMAIN 4, HUMAN
- ANTI-MBD4
- MW:
- 0
- Product Categories:
-
- Antibodies for EpigeneticsAntibodies for Gene Regulation and Expression
- Antibodies for Gene Regulation and Expression
- Antibodies in Chromatin Remodeling
- Antibodies to Modifying Enzymes/DNA MethylationCell Biology
- Antibodies to Transcription RegulatorsAlphabetical Index
- Functional Profiling of Stem Cells
- M
- Other
- Stem Cell Biology
- Mol File:
- Mol File
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ANTI-MBD4 Chemical Properties
- storage temp.
- −20°C
- form
- buffered aqueous solution
- biological source
- rabbit
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Safety Information
- Safety Statements
- 23-24/25
- WGK Germany
- -
MSDS
- Language:English Provider:SigmaAldrich
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ANTI-MBD4 Usage And Synthesis
Biological Activity
MBD4 (methyl-CpG binding domain 4, DNA glycosylase) is involved in the maintenance of genomic integrity. It acts as a DNA repair protein in the DNA mismatch repair (MMR) system. During DNA repair, MBD4 couples with MMR protein MLH1 (mutL homolog 1) th at binds to the methyl-CpG-containing DNA to perform endonuclease activity. MBD4 also has impact on glycosylase/lyase activity in a pathway of base excision repair. It has been reported th at mutation in MED1 activity may cause irregular DNA damage and tumor development.