Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Chemical Properties

Boiling point:

534.6±50.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

insoluble in H2O; ≥106.4 mg/mL in EtOH; ≥125.4 mg/mL in DMSO

form 

Solid

pka

10.95±0.20(Predicted)

color 

Light yellow to yellow

InChIKey

RLKRLNQEXBPQGQ-OZOXKJRCSA-N

SMILES

Clc1c(ccc(c1)C#N)O[C@H]2[C@@H](Cc4c2cccc4)N3C[C@@H](CCC3)N

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- Usage And Synthesis

Uses

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

Biological Activity

sar7334 is a potent trpc6(transient receptor potential cation channel, subfamily c, member 6) inhibitor.

in vivo

References

[1] Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299. DOI:10.1038/s41598-017-00406-2
[2] Chauvet S, et al. Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain. Front Pharmacol. 2016 Dec 12;7:486. DOI:10.3389/fphar.2016.00486
[3] Maier T, et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol. 2015 Jul;172(14):3650-60. DOI:10.1111/bph.13151