ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > K145 (hydrochloride)
K145 (hydrochloride)
K145 (hydrochloride) Basic information
- Product Name:
- K145 (hydrochloride)
- Synonyms:
-
- SphK2 inhibitor
- SPHK2 INHIBITOR;K 145 HYDROCHLORIDE;K-145 HYDROCHLORIDE
- K145 (hydrochloride)
- K145(HCl)
- 3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione hydrochloride (1:1)
- 3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione hydrochloride
- K14 (hydrochloride)
- K145 hydrochloride >=98% (HPLC)
- CAS:
- 1449240-68-9
- MF:
- C18H25ClN2O3S
- MW:
- 384.9207
- Product Categories:
-
- API
- Mol File:
- 1449240-68-9.mol
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K145 (hydrochloride) Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- InChI
- 1S/C18H24N2O3S.ClH/c1-2-3-13-23-15-9-7-14(8-10-15)5-4-6-16-17(21)20(12-11-19)18(22)24-16;/h6-10H,2-5,11-13,19H2,1H3;1H/b16-6-;
- InChIKey
- HADFDMGQKBGVAV-NKBLJONXSA-N
- SMILES
- S1\C(=C/CCc2ccc(cc2)OCCCC)\C(=O)N(C1=O)CCN.Cl
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K145 (hydrochloride) Usage And Synthesis
Uses
K145 hydrochloride has been used in the analysis of apoptosis.
General Description
K145 hydrochloride (3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is an analog of sphingosine.
Biochem/physiol Actions
It has the ability to prevent leukemia cell growth in vitro.
in vivo
K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice[1].
| Animal Model: | BALB/c-nu mice injected with U937 cells[1] |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Inhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed. |
IC 50
SphK2
K145 (hydrochloride)Supplier
Shanghai Boyle Chemical Co., Ltd.
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- sales@boylechem.com
Haoyuan Chemexpress Co., Ltd.
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- 021-58950125
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MedChemexpress LLC
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- 021-58955995
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Bide Pharmatech Ltd.
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- 400-400-164-7117 18317119277
- product02@bidepharm.com
LETOPHARM LIMITED
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- +86-21-5821 5861
- sales@letopharm.com