2-(4-Isopropylpheny)-4H-chroMen-4-one Chemical Properties

Melting point:

63-64 °C(Solv: ethanol (64-17-5))

Boiling point:

389.8±42.0 °C(Predicted)

Density 

1.152±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: soluble20mg/mL, clear

form 

powder

color 

white to beige

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

45

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

2-(4-Isopropylpheny)-4H-chroMen-4-one Usage And Synthesis

Uses

2-[4-(1-Methylethyl)phenyl4H-1-benzopyran-4-one is a potent and selective tankyrase (TNKS) inhibitor affecting cell proliferation with potential treatment for cancers. Flavonoid compound with anti-cancer/ anti-bacterial properties.

Biological Activity

mn-64 is a type of flavone that act as a potent and selective tankyrase inhibitor (ic50 = 6 and 72 nm for tnks1 and tnks2, respectively). [1]tankytase (tnks) is a member of poly adp ribose polymerases (parps). there are two related homologue, tnks1 and tnks2 that are mostly located in the nuclear pore, cytoplasm, mitotic centrosomes and the golgi apparatus. they involve in cellular functions such as regulation of cell proliferation and promoting telomere elongation in human cells. [1]during an assay for screening flavone tnks inhibitors, mn-64 is discovered for abrogating stf luciferase activity at 200nm and potently inhibiting tnks1 with ic50 of 6nm. it also selectively inhibits tnks1 and tnks2 without affecting any other parps. moreover, mn-64 is prominently more selective than other tnks inhibitors such as xav939. [1]

Biochem/physiol Actions

MN-64 is a very potent inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). The compound MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system.

References

1. narwal m, koivunen j, haikarainen t et al. discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. j med chem. 2013 oct 24;56(20):7880-9.

2-(4-Isopropylpheny)-4H-chroMen-4-one(92831-11-3)Related Product Information

• MM-102