2-CHLORO-2,2-DIFLUOROACETOPHENONE Chemical Properties

Melting point:

102-103 °C

Boiling point:

94-96 °C35 mm Hg(lit.)

Density 

1.293 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.497(lit.)

Flash point:

163 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Difficult to mix.

form 

liquid

color 

Clear, colourless

BRN 

2251448

CAS DataBase Reference

384-67-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37

RIDADR 

UN 3334

WGK Germany 

3

F 

19

Hazard Note 

Irritant

HS Code 

29147000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-CHLORO-2,2-DIFLUOROACETOPHENONE Usage And Synthesis

Description

Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.

Uses

2-Chloro-2,2-difluoroacetophenone can be used:

• As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
• As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
• As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

General Description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.

2-CHLORO-2,2-DIFLUOROACETOPHENONE(384-67-8)Related Product Information

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• 4'-CHLORO-2',6'-DIFLUOROACETOPHENONE
• A-CHLORO-2',4'-DIFLUOROACETOPHENONE