Mal-amido-PEG2-TFP ester Chemical Properties

storage temp. 

Storage temp. -20°C

solubility 

Soluble in DMSO, DCM, DMF

form 

Solid

Appearance

White to off-white Solid

Mal-amido-PEG2-TFP ester Usage And Synthesis

Description

Mal-amido-PEG2-TFP ester is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains.

Uses

Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Mal-amido-PEG2-TFP ester(1431291-44-9)Related Product Information

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