TAMRA-PEG3-Azide Chemical Properties

storage temp. 

Storage temp. -20°C

solubility 

Soluble in Water, DMSO, DMF, DCM

form 

Solid

color 

Brown to dark brown

InChIKey

YREJCORUQQJQHB-UHFFFAOYSA-N

SMILES

C(C1C=C(C(=O)NCCOCCOCCOCCN=[N+]=[N-])C=CC=1C1=C2C=CC(N(C)C)=CC2=[O+]C2C=C(N(C)C)C=CC1=2)(=O)[O-]

TAMRA-PEG3-Azide Usage And Synthesis

Description

TAMRA-PEG3-Azide is a TAMRA red-fluorescent dye linker, with excitation/emission maximum 553/575 nm, containing an azide group, which enables Click Chemistry.

Uses

TAMRA-PEG3-Azide is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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