t-Boc-Aminoxy-PEG4-Tos
t-Boc-Aminoxy-PEG4-Tos Basic information
- Product Name:
- t-Boc-Aminoxy-PEG4-Tos
- Synonyms:
-
- t-Boc-Aminoxy-PEG4-Tos
- Boc-Aminooxy-PEG4-Tos
- Boc-Aminoxy-PEG4-Tos
- t-Boc-Aminooxy-PEG4-Tos
- 3,6,9,12-Tetraoxa-2-azatetradecanoic acid, 14-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
- t-Boc-Aminooxy-PEG4-Tos boc
- CAS:
- 1807539-01-0
- MF:
- C20H33NO9S
- MW:
- 463.54
- Mol File:
- 1807539-01-0.mol
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t-Boc-Aminoxy-PEG4-Tos Chemical Properties
- storage temp.
- Storage temp. 2-8°C
- form
- Viscous Liquid
- color
- Colorless to light yellow
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t-Boc-Aminoxy-PEG4-Tos Usage And Synthesis
Description
t-Boc-Aminooxy-PEG4-Tos is a bifunctional crosslinker reagent with a t-Boc-aminooxy group and a tosyl group. The tosyl group is a very good leaving group for nucleophilic substitution. The protected aminooxy can be deprotected under mild acidic conditions. PEG5 spacer increases solubility in aqueous media.
Uses
Boc-Aminooxy-PEG4-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
t-Boc-Aminoxy-PEG4-TosSupplier
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