Ilexhainanoside D
Ilexhainanoside D Basic information
- Product Name:
- Ilexhainanoside D
- Synonyms:
-
- Ilexhainanoside D
- Olean-12-ene-23,28-dioic acid, 3,19-dihydroxy-, 28-β-D-glucopyranosyl ester, (3β,4β,19α)-
- CAS:
- 1137648-52-2
- MF:
- C36H56O11
- MW:
- 664.83
- Mol File:
- 1137648-52-2.mol
Ilexhainanoside D Chemical Properties
- Boiling point:
- 788.1±60.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- pka
- 4.47±0.70(Predicted)
Ilexhainanoside D Usage And Synthesis
Uses
Ilexhainanoside D is the main triterpenoid saponin extracted from Ilex hainanensis Merr., and the combination of Ilexhainanoside D and ilexsaponin A1 has anti-inflammation effect[1].
in vivo
The combination of Ilexhainanoside D and Ilexsaponin A (60, 120 or 240?mg/kg; for 8 weeks) treatment significantly reduces the severity of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet in a dose-dependent manner. The combination of Ilexhainanoside D and Ilexsaponin A treatment decreases the ratio of Firmicutes/Bacteroidetes, reduces the relative abundance of Desulfovibrio and increases the relative abundance of Akkermansia. The intestinal barrier is improved as evidenced by the upregulation of the expression of zonula occludens-1 (ZO-1) and occludin in the ileum. The combination of Ilexhainanoside D and Ilexsaponin A treatment reduces the entry of LPS into the circulation and decreases the hepatic gene expression levels of proinflammatory cytokines[1].
References
[1] Zhao W, et al. The combination of Ilexhainanoside D and ilexsaponin A1 reduces liver inflammation and improves intestinal barrier function in mice with high-fat diet-induced non-alcoholic fatty liver disease. Phytomedicine. 2019 Jul 26;63:153039. DOI:10.1016/j.phymed.2019.153039
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Ilexhainanoside D(1137648-52-2)Related Product Information
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- Bufa-20,22-dienolide, 3,5,14-trihydroxy-19-oxo-, (3beta,5beta)-
- poricoic acid A 3-methyl ester
- Hydroxyecdysone
- ALLEOSIDE A
- Bufalin
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- beta-Sitosterol
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- ilexsaponin B1
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- Ilexoside K
- Gadermandiol
- Tokinolide B
- Forsythoside I
- 6'-O-beta-Apiofuranosylsweroside
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- Aloeresin D