A[5']P5[5']A AMMONIUM SALT Chemical Properties

storage temp. 

-20°C

solubility 

H₂O: 50 mg/mL

form 

powder

color 

white with faint yellow cast

biological source

synthetic (organic)

Water Solubility 

H2O: 50mg/mL

InChI

1S/C10H14N5O8P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(21-7)3-20-25(16,17)23-26(18,19)22-24/h1-2,4-7H,3,24H2,(H,16,17)(H,18,19)(H2,11,12,13)/t6-,7+/m0/s1

InChIKey

LWOSDYWLTWLFID-NKWVEPMBSA-N

SMILES

O[C@@H]1[C@@H](COP(OP(O)(OP(O)(OP(O)(OP(O)(OC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N(C=N3)C4=C3C(N)=NC=N4)O2)=O)=O)=O)=O)(O)=O)O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@@H]1O

Safety Information

WGK Germany 

3

F 

10-21

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

A[5']P5[5']A AMMONIUM SALT Usage And Synthesis

Uses

Diadenosine pentaphosphate pentaammonium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes[1][2].

Biochem/physiol Actions

A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In heart, it increases contractile force and action potential duration, and shows an anti-β-adrenergic effect.

IC 50

Human Endogenous Metabolite

References

[1] L Giraldez, et al. Adenosine triphosphate and diadenosine pentaphosphate induce [Ca(2+)](i) increase in rat basal ganglia aminergic terminals. J Neurosci Res. 2001 Apr 15;64(2):174-82. DOI:10.1002/jnr.1063
[2] Jesús Pintor, et al. Presence of diadenosine polyphosphates in human tears. Pflugers Arch. 2002 Jan;443(3):432-6. DOI:10.1007/s004240100696

A[5']P5[5']A AMMONIUM SALT(102783-61-9)Related Product Information

• (+)-ALPHA-BROMOCAMPHOR-PI-SULFONIC ACID AMMONIUM SALT,ALPHA-BROMOCAMPHOR-PI-SULFONIC ACID AMMONIUM SALT
• 8-Anilino-1-naphthalenesulfonic acid ammonium salt
• BENZENE SULFONIC ACID AMMONIUM SALT
• A[5']P5[5']A AMMONIUM SALT
• 2'-Deoxyadenosine 5'-triphosphate
• Adenosine triphosphate
• ALGINIC ACID AMMONIUM SALT
• AMIDOSULFONIC ACID AMMONIUM SALT,AMINOSULFONIC ACID AMMONIUM SALT
• AMMONIUM SALT OF NITROSOPHENYLHYDROXYLAMINE
• BENZOIC ACID AMMONIUM SALT
• ACRYLIC ACID, AMMONIUM SALT POLYMER
• AURINTRICARBOXYLIC ACID AMMONIUM SALT
• APDC AMMONIUM SALT,APDTC AMMONIUM SALT,AMMONIUM PYRROLIDINEDITHIOCARBAMATE AMMONIUM SALT
• 3'-DEOXYADENOSINE 5'-TRIPHOSPHATE SODIUM SALT
• adenosine 5'-tetraphosphate
• BOC-N-EPSILON-ALLYLOXYCARBONYL-L-LYSINE DICYCLOHEXYL AMMONIUM SALT
• ADP-HPD AMMONIUM SALT DIHYDRATE
• ALLYLOXYCARBONYL-N-DELTA-BOC-L-ORNITHINE DICYCLOHEXYL AMMONIUM SALT