Ammonium 1-pyrrolidinedithiocarbamate Chemical Properties

Melting point:

153-155 °C(lit.)

Density 

1.117 (estimate)

refractive index 

1.5300 (estimate)

storage temp. 

Store at +2°C to +8°C.

solubility 

190g/l

form 

Powder/Solid

color 

White to off-white

PH

6-7 (50g/l, H2O, 20℃)

Water Solubility 

50 g/L (20 ºC)

Sensitive 

Hygroscopic

BRN 

3730472

Stability:

Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference

5108-96-3(CAS DataBase Reference)

EPA Substance Registry System

1-Pyrrolidinecarbodithioic acid, ammonium salt (5108-96-3)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36-37/39

WGK Germany 

3

F 

3

TSCA 

Yes

HS Code 

29339990

MSDS

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Ammonium 1-pyrrolidinedithiocarbamate Usage And Synthesis

Description

Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 μM). At 300 μM, it prevents TNF-α gene expression and protein production in human monocytes after LPS application. In vascular smooth muscle cells, PDTC (10 μM) arrests the cell cycle at the G₁ phase with upregulation of p21^Cip1 through the p38 MAPK pathway. PDTC (100 μM) also has antioxidant properties.

Chemical Properties

pale yellow crystalline solid

Uses

Ammonium pyrrolidinedithiocarbamate has been used:

• to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
• to reduce neutrophil activity in rats
• to prevent Ca²⁺ influx in adriamycin (ADR)-treated podocytes

to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells

Uses

1-Pyrrolidinecarbodithioic Acid induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. It also prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA;

General Description

Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.

Biochem/physiol Actions

Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

Purification Methods

Purify the salt by recrystallising twice by dissolving in MeOH and adding Et2O. It has also been purified by recrystallisation from EtOH. It is used for the precipitation of As, Bi, Cd, Co, Cu, Fe, Mn, Ni, Pb, Sb, Su, V and Zn from acidic solutions [Kinrade & van Loon Anal Chem 46 1894 1974]. The ethyl ester has b 87-89o/0.01mm. [Synthesis and Polarography: Kitagawa & Taku Bull Chem Soc Jpn 64 2151 1973, Malissa & Sch.ffmann Mikrochim Acta 187 1955, Beilstein 20 III/IV 195, 20/1 V 331.]

Ammonium 1-pyrrolidinedithiocarbamate(5108-96-3)Related Product Information

• Ammonium acetate
• Ammonium hydroxide
• Ammonium formate
• Phenyl chlorothionocarbonate
• N-Methyl-2-pyrrolidone
• Ammonium chloride
• Ammonium sulfate
• Thiobenzoic acid
• Polyvinylpyrrolidone
• 5-Pyrazolecarboxylic acid
• Ammonium nitrate
• AMMONIUM
• Ammonium dithiocarbamate
• AMMONIUM CARBAMATE
• Ammonium 1-pyrrolidinedithiocarbamate
• (2,6-DICHLORO-4-PYRIDYL)METHYL PYRROLIDINE-1-CARBODITHIOATE
• 2-OXO-2-(3-OXOTETRAHYDRO-1H-PYRAZOL-1-YL)ETHYL 1-PYRROLIDINECARBODITHIOATE
• (3-CHLORO-5-(TRIFLUOROMETHYL)(2-PYRIDYLTHIO))PYRROLIDINYLMETHANE-1-THIONE