ANTI-PARP
ANTI-PARP Basic information
- Product Name:
- ANTI-PARP
- Synonyms:
-
- ANTI-PARP-1, BOVINE (RABBIT)
- ANTI-POLY(ADP-RIBOSE) POLYMERASE
- ANTI-POLY(ADP-RIBOSE) POLYMERASE-1
- ANTI-POLY(ADP-RIBOSE) POLYMERASE (AB-1), HUMAN
- ANTI-POLY(ADP-RIBOSE) POLYMERASE (AB-1) RABBIT PAB
- ANTI-POLY(ADP)-RIBOSE POLYMERASE (AB-3), BOVINE
- ANTI-PARP
- ANTI-PARP-1
- MW:
- 0
- Mol File:
- Mol File
ANTI-PARP Chemical Properties
- storage temp.
- -20°C
- form
- buffered aqueous solution
MSDS
- Language:English Provider:SigmaAldrich
ANTI-PARP Usage And Synthesis
Uses
Monoclonal Anti-PARP (Cleaved-Asp214) antibody has been used in western blotting and immunohistochemical staining.
Uses
Anti-poly (ADP-Ribose) polymerase is used for western blots, immunochemistry, immunofluorescence and immunoprecipitation.
General Description
Monoclonal Anti-PARP (mouse IgG1) is produced by immunizing mice with purified calf thymus poly (ADPribose) polymerase as the antigen. This antibody recognizes a 116kDa protein which corresponds to PARP and the 85kDa apoptosis induced cleavage product of prICE (proteinase resembling interleukin 1b-converting enzyme) and CPP32 (cysteine protease). It also recognizes PARP from mouse, rat, hamster and primate sources, but fails to detect avian PARP.
Poly (ADP-ribose) polymerase 1 (PARP1)/PARP is encoded by the gene mapped to human chromosome 1q42. It is a nuclear protein with molecular mass of 113kDa and is characterized with three functional domains. It belongs to the PARP superfamily.
Biochem/physiol Actions
PARP1 poly(ADP-ribose) polymerase 1) and its enzymatic product PAR controls cellular processes like DNA repair, chromatin remodeling, transcription and cell death. PARP1 regulates transcription. PARP1 can induce or block homologous recombination (HR).