2-PIPERAZIN-1-YL-BENZALDEHYDE Chemical Properties

Boiling point:

355.0±27.0 °C(Predicted)

Density 

1.123±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

8.86±0.10(Predicted)

CAS DataBase Reference

736991-52-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2933599590

2-PIPERAZIN-1-YL-BENZALDEHYDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-piperazine-1-benzaldehyde from piperazine and 2-fluorobenzaldehyde: 2-fluorobenzaldehyde (1.0 g, 8.1 mmol) was dissolved in N,N-dimethylformamide (15 ml) in a 50 ml round bottom flask. Piperazine (836 mg, 9.7 mmol) and potassium carbonate (1.68 g, 12.2 mmol) were then added and the reaction was carried out at 130 °C for 6 hours. After completion of the reaction, it was cooled to room temperature, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic phases were combined and dried over anhydrous sodium sulfate. Purification was carried out by silica gel column chromatography (petroleum ether: ethyl acetate = 5:1; dichloromethane: methanol = 10:1), and the target compound 2-piperazine-1-benzaldehyde (760 mg, 49.4% yield) was obtained after concentration.

References

[1] Patent: CN105777632, 2016, A. Location in patent: Paragraph 0481; 0482; 0483

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