Pinostrobin Chemical Properties

Melting point:

100°C

Boiling point:

494.9±45.0 °C(Predicted)

Density 

1.284±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 12 mg/ml

form 

A crystalline solid

pka

7.40±0.40(Predicted)

color 

White to yellow

LogP

3.591 (est)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Pinostrobin Usage And Synthesis

Description

Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM. Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC₅₀s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively). Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC₅₀ = 10.2 μM) in a panel of eight cancer cell lines (IC₅₀s = >30 μM).

Uses

Pinostrombin is a useful research chemical that can be used for chemical fingerprinting, isolating, and characterizing of polyphenol compounds. It can also be used as a potential compound for TMPRSS2 inhibition for Covid-19 therapy.

Definition

ChEBI: A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively.

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