2,5-Dimethoxynaphthalene Chemical Properties

Melting point:

56-60 °C(lit.)

Boiling point:

123°C 0,8mm

Density 

1.097±0.06 g/cm3(Predicted)

Flash point:

123°C/0.8mm

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Dichloromethane

form 

Solid

color 

Brown

BRN 

1945987

CAS DataBase Reference

3900-49-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

41

Safety Statements 

26-36/39

WGK Germany 

3

HS Code 

2909309090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,5-Dimethoxynaphthalene Usage And Synthesis

Chemical Properties

Brown Solid

Uses

Intermediate in the production of tetralin derivatives

Synthesis

In a round-bottomed flask equipped with a magnetic stirrer, 1.6 g (10.0 mmol) of 1,6-dihydroxynaphthalene (compound 39, purchased from Tokyo Chemical Industry Co., Ltd.) was dissolved in 15 mL of N,N-dimethylformamide (DMF). Subsequently, 14.2 g (100.0 mmol) of iodomethane (purchased from Wako Pure Chemical Industries, Ltd.) and 13.8 g (100.0 mmol) of potassium carbonate (purchased from Wako Pure Chemical Industries, Ltd.) were added to the solution. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was extracted by adding dichloromethane and water to the reaction mixture and the organic layer was separated and washed with distilled water. The solvent was removed by distillation under reduced pressure to give 1.7 g (yield: 90%) of 2,5-dimethoxynaphthalene (compound 40) as a colorless liquid.

References

[1] Patent: US2017/342031, 2017, A1. Location in patent: Paragraph 0643

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