Basic information Safety Supplier Related

VOACANGINE

Basic information Safety Supplier Related

VOACANGINE Basic information

Product Name:
VOACANGINE
Synonyms:
  • VOACANGINE
  • 12-Methoxyibogamine-18-carboxylic acid methyl ester
  • Carbomethoxyibogaine
  • Ibogamine-18-carboxylic acid, 12-methoxy-, methyl ester
  • (-)-Voacangine
CAS:
510-22-5
MF:
C22H28N2O3
MW:
368.47
Mol File:
510-22-5.mol
More
Less

VOACANGINE Chemical Properties

Melting point:
223-224℃ (dec.)
Density 
1.25±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
Store at -20°C,protect from light
solubility 
DMF: 16 mg/ml; DMSO: 16 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.33 mg/ml
form 
A crystalline solid
color 
White to off-white
More
Less

VOACANGINE Usage And Synthesis

Description

This alkaloid is of widespread occurrence, being found in Stemmadenia species and also is Vocanga africana, v. dregii and V. obtusa. It forms colourless needles when crystallized from MeOH and has [0'10 - 42° (c 1.0, CHCI3). It sublimes under vacuum at 135°CjO.01 mm and is readily soluble in CHC13 or Me2CO, but only sparingly so in EtOH or MeOH. Hydrolysis with KOH followed by acidification with HCl yields Ibogaine (q.v.).

Uses

(-)-Voacangine is a bisindole alkaloid with ether-?a-?go-?go-?related gene channel blocker activity in vitro. hERG channel blocker.

Definition

ChEBI: (-)-voacangine is a monoterpenoid indole alkaloid with formula C22H28N2O3, isolated from several plant species. It has a role as an angiogenesis inhibitor, an antineoplastic agent and a plant metabolite. It is a monoterpenoid indole alkaloid, a tertiary amino compound, a methyl ester, an organic heteropentacyclic compound and an alkaloid ester. It is a conjugate base of a (-)-voacangine(1+).

References

lanot, Goutarel., Compt. rend., 241,986 (1955) Stauffacher, Seebeck., Helv. Chim. Acta, 41,169 (1958) Watts, Collera, Sandoval., Tetrahedron, 2, 173 (1958) Schuler, Verbeck, Warren.,J. Chern. Soc., 4776 (1958) Bartlett, Dickel, Taylor.,J. Amer. Chern. Soc., 80, 126 (1958) Renner, Prins, Stoll., Helv. Chim. Acta, 42,1572 (1959) Budzikiewicz etal., Bull. Soc. Chim. Fr., 1899 (1963)

VOACANGINESupplier

BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
ALB Technology Limited
Tel
702-983-3769
Email
sales@albtechnology.com
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Email
aileen@chemfaces.com
EMMX Biotechnology LLC
Tel
888-539-0666
Email
info@emmx.com
BOC Sciences
Tel
16314854226
Email
info@bocsci.com