Basic information Safety Supplier Related

VOACANGINE

Basic information Safety Supplier Related

VOACANGINE Basic information

Product Name:
VOACANGINE
Synonyms:
  • VOACANGINE
  • 12-Methoxyibogamine-18-carboxylic acid methyl ester
  • Carbomethoxyibogaine
  • Ibogamine-18-carboxylic acid, 12-methoxy-, methyl ester
  • (-)-Voacangine
CAS:
510-22-5
MF:
C22H28N2O3
MW:
368.47
Mol File:
510-22-5.mol
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VOACANGINE Chemical Properties

Melting point:
223-224℃ (dec.)
Density 
1.25±0.1 g/cm3 (20 ºC 760 Torr)
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VOACANGINE Usage And Synthesis

Description

This alkaloid is of widespread occurrence, being found in Stemmadenia species and also is Vocanga africana, v. dregii and V. obtusa. It forms colourless needles when crystallized from MeOH and has [0'10 - 42° (c 1.0, CHCI3). It sublimes under vacuum at 135°CjO.01 mm and is readily soluble in CHC13 or Me2CO, but only sparingly so in EtOH or MeOH. Hydrolysis with KOH followed by acidification with HCl yields Ibogaine (q.v.).

Uses

(-)-Voacangine is a bisindole alkaloid with ether-?a-?go-?go-?related gene channel blocker activity in vitro. hERG channel blocker.

References

lanot, Goutarel., Compt. rend., 241,986 (1955) Stauffacher, Seebeck., Helv. Chim. Acta, 41,169 (1958) Watts, Collera, Sandoval., Tetrahedron, 2, 173 (1958) Schuler, Verbeck, Warren.,J. Chern. Soc., 4776 (1958) Bartlett, Dickel, Taylor.,J. Amer. Chern. Soc., 80, 126 (1958) Renner, Prins, Stoll., Helv. Chim. Acta, 42,1572 (1959) Budzikiewicz etal., Bull. Soc. Chim. Fr., 1899 (1963)

VOACANGINESupplier

ALB Technology Limited
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Shanghai EFE Biological Technology Co., Ltd.
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