Carbidopa Monohydrate Chemical Properties

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids.

color 

White to Off-White

CAS DataBase Reference

38821-49-7(CAS DataBase Reference)

Safety Information

WGK Germany 

3

RTECS 

MW5300000

HazardClass 

IRRITANT

HS Code 

2928002500

Toxicity

mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.

Carbidopa Monohydrate Usage And Synthesis

Chemical Properties

white or yellowish-white powder. almost odorless. combined with levodopa for Parkinson's disease and Parkinson's syndrome.

Originator

Sinemet,Merck Sharp and Dohme,Italy,1974

Uses

Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.

Uses

Carbidopa may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Definition

ChEBI: Carbidopa is the hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor, an antiparkinson drug, a dopaminergic agent and an antidyskinesia agent. It is a member of hydrazines, a hydrate, a monocarboxylic acid and a member of catechols. It contains a carbidopa (anhydrous).

brand name

Lodosyn (Bristol-Myers Squibb).

Therapeutic Function

Muscle relaxant, Antiparkinsonian

General Description

Carbidopa, (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, is a whitecrystalline powder, slightly soluble in water (pK_a＝7.8).Carbidopa is absorbed slower than levodopa and is 36%plasma protein bound.Carbidopa is metabolized to twomain metabolites (α-methyl-3-methoxy-4-hydroxyphenylpropionicacid and α-methyl-3,4-dihydroxyphenylpropionicacid). These two metabolites are primarily eliminated in theurine unchanged or as glucuronide conjugates. Unchangedcarbidopa accounts for 30% of the total urinary excretion.No drug interactions have been described.

Carbidopa Monohydrate(38821-49-7)Related Product Information

• CARBIDOPA EDMF,S-(-)-CARBIDOPA,ANHYDROUS,(S)-CARBIDOPA,S(-)-CARBIDOPA,S(-)-CARBIDOPA >98% L-AROMATIC AMINO ACI D
• 3-(4-Hydroxyphenyl)propionic acid
• MELIBIOSE
• L(+)-Lactic acid
• Citric acid monohydrate
• Caronic anhydride
• METHYLCARBIDOPA
• (s)-(-)-Carbidopa-d3
• DL-Carbidopa
• (S)-(-)-CARBIDOPA-D3 H2O (RING-D3)
• CARBIDOPA-D5
• Sinemet
• Carbidopa Monohydrate
• CARBIDOPA RELATED COMPOUND A (25 MG) (3-O-METHYLCARBIDOPA)
• S(-)-CARBIDOPA N/H
• CARBIDOPA RELATED COMPOUND A (50 MG) (3-O-METHYLCARBIDOPA)
• (S)-(-)-Carbidopa-D32O (ring-D3)
• S(-)-CARBIDOPA:2-HYDROXYPROPYL-