Carbidopa Monohydrate

Product Name: Carbidopa Monohydrate
CAS No.: 38821-49-7
Chemical Name: Carbidopa Monohydrate
Synonyms: lodosyn;CARBIDOPA;Carbidopa RS;CARBIDOPA,USP;Carbidopa CRS;CARBIDOPA HYDRATE;Carbidopa(CEP/FDA);Carbidopa (400 mg);Carbidopa Capsules;CARBIDOPA 1-HYDRATE
CBNumber: CB7445183
Molecular Formula: C10H16N2O5
Formula Weight: 244.25
MOL File: 38821-49-7.mol

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Carbidopa Monohydrate Property

storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids.
color: White to Off-White
CAS DataBase Reference: 38821-49-7(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: MW5300000
HazardClass: IRRITANT
HS Code: 2928002500
Toxicity: mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1655
Product name: Carbidopa
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1g
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP060
Product name: Carbidopa
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $229
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1095506
Product name: Carbidopa
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 400mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: C2450
Product name: Carbidopa Monohydrate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $73
Updated: 2024/03/01

TCI Chemical

Product number: C2450
Product name: Carbidopa Monohydrate
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $25
Updated: 2024/03/01

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Carbidopa Monohydrate Chemical Properties,Usage,Production

Chemical Properties

white or yellowish-white powder. almost odorless. combined with levodopa for Parkinson's disease and Parkinson's syndrome.

Originator

Sinemet,Merck Sharp and Dohme,Italy,1974

Uses

Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.

Uses

Carbidopa may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Definition

ChEBI: Carbidopa is the hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor, an antiparkinson drug, a dopaminergic agent and an antidyskinesia agent. It is a member of hydrazines, a hydrate, a monocarboxylic acid and a member of catechols. It contains a carbidopa (anhydrous).

brand name

Lodosyn (Bristol-Myers Squibb).

Therapeutic Function

Muscle relaxant, Antiparkinsonian

General Description

Carbidopa, (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, is a whitecrystalline powder, slightly soluble in water (pK_a＝7.8).Carbidopa is absorbed slower than levodopa and is 36%plasma protein bound.Carbidopa is metabolized to twomain metabolites (α-methyl-3-methoxy-4-hydroxyphenylpropionicacid and α-methyl-3,4-dihydroxyphenylpropionicacid). These two metabolites are primarily eliminated in theurine unchanged or as glucuronide conjugates. Unchangedcarbidopa accounts for 30% of the total urinary excretion.No drug interactions have been described.

Carbidopa Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbidopa Monohydrate Suppliers

Americas 1 Brazil 2 China 246 Europe 2 Finland 2 France 1 Germany 2 India 30 Israel 2 Japan 4 Poland 1 Singapore 1 Switzerland 2 United Arab Emirates 1 United Kingdom 4 United States 22 Global 323

Hubei Weideli Chemical Reagent Co.，Ltd.

Tel: 13339985473
Email: C13339985473@163.com
Country: China
ProdList: 3459
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3576
Advantage: 66

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35906
Advantage: 56

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
Advantage: 52

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14443
Advantage: 57

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View Lastest Price from Carbidopa Monohydrate manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Carbidopa 38821-49-7
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-09-26

Hebei Duling International Trade Co. LTD

Product: Carbidopa Monohydrate 38821-49-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 300MT/month
Release date: 2022-11-23

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Carbidopa Monohydrate 38821-49-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-11

38821-49-7, Carbidopa MonohydrateRelated Search:

CARBIDOPA EDMF,S-(-)-CARBIDOPA,ANHYDROUS,(S)-CARBIDOPA,S(-)-CARBIDOPA,S(-)-CARBIDOPA >98% L-AROMATIC AMINO ACI D 3-(4-Hydroxyphenyl)propionic acid MELIBIOSE L(+)-Lactic acid Citric acid monohydrate Caronic anhydride METHYLCARBIDOPA (s)-(-)-Carbidopa-d3 DL-Carbidopa (S)-(-)-CARBIDOPA-D3 H2O (RING-D3) CARBIDOPA-D5 Sinemet Carbidopa Monohydrate CARBIDOPA RELATED COMPOUND A (25 MG) (3-O-METHYLCARBIDOPA) S(-)-CARBIDOPA N/H CARBIDOPA RELATED COMPOUND A (50 MG) (3-O-METHYLCARBIDOPA) (S)-(-)-Carbidopa-D32O (ring-D3) S(-)-CARBIDOPA:2-HYDROXYPROPYL-

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38821-49-7

38812-49-7

156-2-26

C10H14N2O4H2O

Inhibitors

Pharmaceutical intermediates

Other APIs