Carbidopa Monohydrate
- Product Name
- Carbidopa Monohydrate
- CAS No.
- 38821-49-7
- Chemical Name
- Carbidopa Monohydrate
- Synonyms
- lodosyn;CARBIDOPA;Carbidopa RS;CARBIDOPA,USP;Carbidopa CRS;CARBIDOPA HYDRATE;Carbidopa(CEP/FDA);Carbidopa (400 mg);Carbidopa Capsules;CARBIDOPA 1-HYDRATE
- CBNumber
- CB7445183
- Molecular Formula
- C10H16N2O5
- Formula Weight
- 244.25
- MOL File
- 38821-49-7.mol
Carbidopa Monohydrate Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids.
- color
- White to Off-White
- CAS DataBase Reference
- 38821-49-7(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- MW5300000
- HazardClass
- IRRITANT
- HS Code
- 2928002500
- Toxicity
- mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- PHR1655
- Product name
- Carbidopa
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $114
- Updated
- 2024/03/01
- Product number
- BP060
- Product name
- Carbidopa
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $229
- Updated
- 2024/03/01
- Product number
- 1095506
- Product name
- Carbidopa
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 400mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- C2450
- Product name
- Carbidopa Monohydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $73
- Updated
- 2024/03/01
- Product number
- C2450
- Product name
- Carbidopa Monohydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 100mg
- Price
- $25
- Updated
- 2024/03/01
Carbidopa Monohydrate Chemical Properties,Usage,Production
Chemical Properties
white or yellowish-white powder. almost odorless. combined with levodopa for Parkinson's disease and Parkinson's syndrome.
Originator
Sinemet,Merck Sharp and Dohme,Italy,1974
Uses
Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.
Uses
Carbidopa may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
Definition
ChEBI: Carbidopa is the hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor, an antiparkinson drug, a dopaminergic agent and an antidyskinesia agent. It is a member of hydrazines, a hydrate, a monocarboxylic acid and a member of catechols. It contains a carbidopa (anhydrous).
brand name
Lodosyn (Bristol-Myers Squibb).
Therapeutic Function
Muscle relaxant, Antiparkinsonian
General Description
Carbidopa, (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, is a whitecrystalline powder, slightly soluble in water (pKa＝7.8).Carbidopa is absorbed slower than levodopa and is 36%plasma protein bound.Carbidopa is metabolized to twomain metabolites (α-methyl-3-methoxy-4-hydroxyphenylpropionicacid and α-methyl-3,4-dihydroxyphenylpropionicacid). These two metabolites are primarily eliminated in theurine unchanged or as glucuronide conjugates. Unchangedcarbidopa accounts for 30% of the total urinary excretion.No drug interactions have been described.
Carbidopa Monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Carbidopa Monohydrate Suppliers
- Tel
- --
- Fax
- --
- bachem.sale@yahoo.com
- Country
- Switzerland
- ProdList
- 291
- Advantage
- 81
View Lastest Price from Carbidopa Monohydrate manufacturers
- Product
- Carbidopa 38821-49-7
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-09-26
- Product
- Carbidopa Monohydrate 38821-49-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 300MT/month
- Release date
- 2022-11-23
- Product
- Carbidopa Monohydrate 38821-49-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-11