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Carbidopa Monohydrate

Product Name
Carbidopa Monohydrate
CAS No.
38821-49-7
Chemical Name
Carbidopa Monohydrate
Synonyms
lodosyn;CARBIDOPA;Carbidopa RS;CARBIDOPA,USP;Carbidopa CRS;CARBIDOPA HYDRATE;Carbidopa(CEP/FDA);Carbidopa (400 mg);Carbidopa Capsules;CARBIDOPA 1-HYDRATE
CBNumber
CB7445183
Molecular Formula
C10H16N2O5
Formula Weight
244.25
MOL File
38821-49-7.mol
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Carbidopa Monohydrate Property

storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids.
color 
White to Off-White
CAS DataBase Reference
38821-49-7(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
MW5300000
HazardClass 
IRRITANT
HS Code 
2928002500
Toxicity
mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1655
Product name
Carbidopa
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$114
Updated
2024/03/01
Sigma-Aldrich
Product number
BP060
Product name
Carbidopa
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
1095506
Product name
Carbidopa
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
400mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
C2450
Product name
Carbidopa Monohydrate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$73
Updated
2024/03/01
TCI Chemical
Product number
C2450
Product name
Carbidopa Monohydrate
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$25
Updated
2024/03/01
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Carbidopa Monohydrate Chemical Properties,Usage,Production

Chemical Properties

white or yellowish-white powder. almost odorless. combined with levodopa for Parkinson's disease and Parkinson's syndrome.

Originator

Sinemet,Merck Sharp and Dohme,Italy,1974

Uses

Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.

Uses

Carbidopa may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Definition

ChEBI: Carbidopa is the hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor, an antiparkinson drug, a dopaminergic agent and an antidyskinesia agent. It is a member of hydrazines, a hydrate, a monocarboxylic acid and a member of catechols. It contains a carbidopa (anhydrous).

brand name

Lodosyn (Bristol-Myers Squibb).

Therapeutic Function

Muscle relaxant, Antiparkinsonian

General Description

Carbidopa, (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, is a whitecrystalline powder, slightly soluble in water (pKa＝7.8).Carbidopa is absorbed slower than levodopa and is 36%plasma protein bound.Carbidopa is metabolized to twomain metabolites (α-methyl-3-methoxy-4-hydroxyphenylpropionicacid and α-methyl-3,4-dihydroxyphenylpropionicacid). These two metabolites are primarily eliminated in theurine unchanged or as glucuronide conjugates. Unchangedcarbidopa accounts for 30% of the total urinary excretion.No drug interactions have been described.

Carbidopa Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbidopa Monohydrate Suppliers

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View Lastest Price from Carbidopa Monohydrate manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Carbidopa 38821-49-7
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-09-26
Hebei Duling International Trade Co. LTD
Product
Carbidopa Monohydrate 38821-49-7
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
300MT/month
Release date
2022-11-23
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Carbidopa Monohydrate 38821-49-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-11

38821-49-7, Carbidopa MonohydrateRelated Search:

CARBIDOPA EDMF,S-(-)-CARBIDOPA,ANHYDROUS,(S)-CARBIDOPA,S(-)-CARBIDOPA,S(-)-CARBIDOPA >98% L-AROMATIC AMINO ACI D 3-(4-Hydroxyphenyl)propionic acid MELIBIOSE L(+)-Lactic acid Citric acid monohydrate Caronic anhydride METHYLCARBIDOPA (s)-(-)-Carbidopa-d3 DL-Carbidopa (S)-(-)-CARBIDOPA-D3 H2O (RING-D3) CARBIDOPA-D5 Sinemet Carbidopa Monohydrate CARBIDOPA RELATED COMPOUND A (25 MG) (3-O-METHYLCARBIDOPA) S(-)-CARBIDOPA N/H CARBIDOPA RELATED COMPOUND A (50 MG) (3-O-METHYLCARBIDOPA) (S)-(-)-Carbidopa-D32O (ring-D3) S(-)-CARBIDOPA:2-HYDROXYPROPYL-

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