CALPHOSTIN C Chemical Properties

Boiling point:

1039.8±65.0 °C(Predicted)

Density 

1.48±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: 1 mg/mL

form 

powder

pka

7.30±0.20(Predicted)

color 

red to brown

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

24/25-36-26

WGK Germany 

3

HS Code 

29209010

Hazardous Substances Data

121263-19-2(Hazardous Substances Data)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

CALPHOSTIN C Usage And Synthesis

Chemical Properties

Dark red solid

Uses

Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.

Uses

Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.

Uses

Potent inhibitor of protein kinase C

Biological Activity

Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM).

Biochem/physiol Actions

Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.

storage

+4°C (desiccate)

CALPHOSTIN C(121263-19-2)Related Product Information

• NS-398
• 4-Hydroxy-1-naphthaldehyde
• 2'-HYDROXY-1'-ACETONAPHTHONE
• 1-ALLYLNAPHTHALENE
• 9-ETHYLPHENANTHRENE
• 4-PHENYL-2-BUTYL ACETATE
• 9-METHYLPHENANTHRENE
• 1,7-DIMETHYLNAPHTHALENE
• 2-Vinylnaphthalene
• ACETIC ACID 3-PHENYL-BUT-3-ENYL ESTER
• 1,2-DIMETHYLNAPHTHALENE
• 2-Naphthaleneethanol
• 2-HYDROXY-1-NAPHTHALDEHYDE
• Divinylbenzene
• calphostin B
• 7-METHYL-2-NAPHTHOL
• 1-Naphthalenol,6-methyl-(9CI)
• 1,8-DIMETHYLPHENANTHRENE