NS-398 Chemical Properties

Melting point:

124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))

Boiling point:

490.6±55.0 °C(Predicted)

Density 

1.377±0.06 g/cm3(Predicted)

RTECS 

PB0473500

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO: >5 mg/mL

form 

solid

pka

6.33±0.10(Predicted)

color 

off-white

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

2935.90.9500

MSDS

• Language:English Provider:SigmaAldrich

NS-398 Usage And Synthesis

Description

NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC₅₀ values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC₅₀ values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively.

Uses

NS-398 is a selective Cox-2 inhibitor neuroprotective agent.

Definition

ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.

Biological Activity

Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .

storage

Store at RT

References

[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46.

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