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AG 490

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AG 490 Basic information

Product Name:
AG 490
Synonyms:
  • AG 490, Tryphostin B42
  • 2-Cyano-3-(3,4-dihydroxyphenyl)-N-benzylacrylamide
  • N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)propenamide
  • TYRPHOSTIN AG 490
  • TYROPHOSTIN AG490
  • TYRPHOSTIN B42
  • TYRPHOSTIN AG 490, 99+%
  • N-Benzyl-2-(3,4-dihydroxybenzylidene)-2-cyanoacetamide
CAS:
134036-52-5
MF:
C17H14N2O3
MW:
294.3
EINECS:
604-604-1
Product Categories:
  • Inhibitor
  • Aromatics
  • All Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Tyrosine Kinase Inhibitors
Mol File:
134036-52-5.mol
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AG 490 Chemical Properties

Melting point:
215
Boiling point:
615.2±55.0 °C(Predicted)
Density 
1.337±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
ethanol: 5 mg/mL
form 
solid
pka
8.82±0.35(Predicted)
color 
yellow
CAS DataBase Reference
134036-52-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38-50-25
Safety Statements 
26-36-61-45
WGK Germany 
1
Hazard Note 
Irritant/Keep Cold under -20C
HS Code 
2926907090

MSDS

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AG 490 Usage And Synthesis

Chemical Properties

Pale Yellow-Green Crystal

Uses

A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.

Uses

Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors.

Definition

ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.

AG 490Supplier

Shanghai Boyle Chemical Co., Ltd.
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969
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isunpharm@qq.com