AG 490
AG 490 Basic information
- Product Name:
- AG 490
- Synonyms:
-
- AG 490, Tryphostin B42
- 2-Cyano-3-(3,4-dihydroxyphenyl)-N-benzylacrylamide
- N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)propenamide
- TYRPHOSTIN AG 490
- TYROPHOSTIN AG490
- TYRPHOSTIN B42
- TYRPHOSTIN AG 490, 99+%
- N-Benzyl-2-(3,4-dihydroxybenzylidene)-2-cyanoacetamide
- CAS:
- 134036-52-5
- MF:
- C17H14N2O3
- MW:
- 294.3
- EINECS:
- 604-604-1
- Product Categories:
-
- Inhibitor
- Aromatics
- All Inhibitors
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Tyrosine Kinase Inhibitors
- Mol File:
- 134036-52-5.mol
AG 490 Chemical Properties
- Melting point:
- 215
- Boiling point:
- 615.2±55.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- ethanol: 5 mg/mL
- form
- solid
- pka
- 8.82±0.35(Predicted)
- color
- yellow
- CAS DataBase Reference
- 134036-52-5(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-50-25
- Safety Statements
- 26-36-61-45
- WGK Germany
- 1
- Hazard Note
- Irritant/Keep Cold under -20C
- HS Code
- 2926907090
MSDS
- Language:English Provider:SigmaAldrich
AG 490 Usage And Synthesis
Chemical Properties
Pale Yellow-Green Crystal
Uses
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
Uses
Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors.
Definition
ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.
AG 490Supplier
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