ABX-1431
ABX-1431 Basic information
- Product Name:
- ABX-1431
- Synonyms:
-
- CS-2856
- ABX1431;ABX 1431
- ABX-1431
- 1-Piperazinecarboxylic acid, 4-[[2-(1-pyrrolidinyl)-4-(trifluoromethyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
- 1,1,1,3,3,3-hexafluoropropan-2-yl 4-{[2-(pyrrolidin-1-yl)-4-(trifluoromethyl)phenyl]me thyl}piperazine-1-carboxylate
- 1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate
- ABX-1431,inhibit,ABX 1431,Monoacylglycerol lipase,ABX1431,MAGL,Inhibitor
- Elcubragistat
- CAS:
- 1446817-84-0
- MF:
- C20H22F9N3O2
- MW:
- 507.39
- Mol File:
- 1446817-84-0.mol
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ABX-1431 Chemical Properties
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- solid
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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ABX-1431 Usage And Synthesis
Description
ABX-1431 (1446817-84-0) is a potent (IC50 = 14 nM in vitro, 2.2 nM in human PC3 cells) and very selective (>100-fold over hABHD6, >200-fold over hPLA2G7) inhibitor of monoacylglycerol lipase (MAGL).1 Active in a rat formalin pain test at 3mg/kg. Orally bioavailable and CNS penetrant.
References
1) Cisar et al. (2018), Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders; J. Med. Chem., 61 9062
ABX-1431Supplier
Fujian boshi pharmaceutical technology co. LTD Gold
- Tel
- 0595-22008920; 18120708884
- 393612455@qq.com
ChemCell Biomedicine Co.,Ltd.
- Tel
- 020-13556033878 2965585218 13556033878
- chemcell@hotmail.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696,15000506266 15000506266
ShangHai Angti Biotechnology Co., Ltd.
- Tel
- 13764913901
- info@angtibio.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
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