UNC2541
UNC2541 Basic information
- Product Name:
- UNC2541
- Synonyms:
-
- UNC2541
- UNC2541; UNC-2541; UNC 2541;
- 2,9,16,18,21-Pentaazabicyclo[15.3.1]heneicosa-1(21),17,19-triene-20-carboxamide, 7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-, (7S)-
- UNC2541,UNC 2541,Inhibitor,Tyro3,TAM Receptor,inhibit,Mer,UNC-2541,Axl
- (S)-7-Amino-N-(4-fluorobenzyl)-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(20),16,18-triene-20-carboxamide
- (7S,16E)-7-amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(20),16,18-triene-20-carboxamide
- UNC2541, 10 mM in DMSO
- (S)-7-amino-N-(4-fluorobenzyl)-8-oxo-2,9,16-triaza-1(2,4)-pyrimidinacyclohexadecaphane-15-carboxamide
- CAS:
- 1612782-86-1
- MF:
- C24H34FN7O2
- MW:
- 471.57
- Product Categories:
-
- APIS
- Mol File:
- 1612782-86-1.mol
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UNC2541 Chemical Properties
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:10.0(Max Conc. mg/mL);21.21(Max Conc. mM)
- form
- Solid
- pka
- 9.48±0.40(Predicted)
- color
- White to off-white
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UNC2541 Usage And Synthesis
Uses
Macrocyclic effect on inhibitory activity a modeling study on mertk inhibitors.MerTK-specific inhibitor.
in vivo
UNC2541 (25 μM; pretreatment around the sciatic nerve half an hour in advance) significantly abolishes the analgesic effect of ozone in CCI mice[2].
| Animal Model: | Adult male SPF-grade ICR mice and C57BL/6 mice, weighing 20-22g and aged 6-8 weeks (anesthetized with sodium pentobarbital and sciatic nerve was ligatured by 4-0 chromic gut sutures to establish Chronic constriction injury (CCI) model)[2] |
| Dosage: | 25 μM |
| Administration: | Pretreatment around the sciatic nerve half an hour in advance. |
| Result: | Significantly abolished the analgesic effect of ozone in CCI mice. |
IC 50
Mer
UNC2541Supplier
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
- Tel
- 17702719238 18971495150;
- sales@sun-shinechem.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com